Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a
multifunctional enzyme that is essential for maintaining cellular homeostasis. APE1 is the …

The base excision repair (BER) pathway is essential for maintaining the stability of DNA in
all organisms and defects in this process are associated with life-threatening diseases. It is …

Combinational therapies provoking cell death are of major interest in oncology. Combining
TORC2 kinase inhibition with the radiomimetic drug Zeocin results in a rapid accumulation …

Main conclusion The present review summarizes recent advances in the understanding of
6mA in DNA as an emergent epigenetic mark with distinctive characteristics, discusses its …

The major human apurinic/apyrimidinic (AP) site endonuclease, APEX1, is a central player
in the base excision DNA repair (BER) pathway and has a role in the regulation of DNA …

Human apurinic/apyrimidinic endonuclease 1 (APE1) has multiple functions in base
excision DNA repair (BER) and other cellular processes. Its eukaryote-specific N-terminal …

Base excision DNA repair (BER) is a key pathway safeguarding the genome of all living
organisms from damage caused by both intrinsic and environmental factors. Most present …

Apurinic/apyrimidinic (AP) endonucleases Nfo (Escherichia coli) and APE1 (human)
represent two conserved structural families of enzymes that cleave AP-site–containing DNA …

The oxidation-induced DNA modification 8-oxo-7, 8-dihydro-2′-deoxyguanosine (8-oxodG)
was recently implicated in the activation and repression of gene transcription. We aimed at a …

Many proteins consist of two or more structural domains: separate parts that have a defined
structure and function. For example, in enzymes, the catalytic activity is often localized in a …