The activation of carboxylic acids for the formation of amides or esters is an important
process usually carried out using the so-called peptide coupling reagents.'The formation of …

Organic chemists working on the synthesis of natural products have long found a special
challenge in the preparation of peptides and proteins. However, more reliable, more efficient …

Peptide coupling methods derived from onium salts based on 1-hydroxybenzotriazole
(HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt) are becoming incorporated in synthetic …

The manipulation of protein structure enables a better understanding of the principles of
protein folding, as well as the development of novel therapeutics and drug-delivery vehicles …

Abstract 1H‐Benzotriazolium 1‐[bis (dimethyl‐amino) methylene]‐5‐chloro‐
hexafluorophosphate (1‐), 3‐oxide (HCTU) is a nontoxic, nonirritating and noncorrosive …

We present a new family of peptide dendrimers based on polyproline helices and cis-4-
amino-l-proline as a branching unit. Dendrimers were synthesized by a convergent solid …

Understanding the mechanisms of biomineralization and the realization of biology-inspired
inorganic materials formation largely depends on our ability to manipulate peptide/solid …

Peptides play key structural and functional roles in biochemistry, pharmacology, and
neurobiology, and are important probes for research in enzymology, immunology, and …

Zeins are maize storages proteins that accumulate inside large vesicles called protein
bodies. γ-Zein lines the inner face of the protein body membrane, and its N-terminal proline …

Besides linear solid phase peptide synthesis, segment condensation in solution and
chemical ligation, convergent peptide synthesis (CPS) was developed in order to enable the …