Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens,
but pro-and anti-viral activities have been reported for coronaviruses. Here, we show that …

Recent commercialization of lentiviral vector (LV)-based cell therapies and successful
reports of clinical studies have demonstrated the untapped potential of LVs to treat diseases …

Extensive studies on HIV-1 have led to the discovery of a variety of structurally and
functionally diverse innate defense factors that target various steps of the retroviral …

To enhance infection, enveloped viruses exploit adhesion molecules expressed on the
surface of host cells. Specifically, phosphatidylserine (PS) receptors–including members of …

Serine incorporator (SERINC) proteins 1–5 (SERINC1-5) are involved in the progression of
several diseases. SERINC2-4 are carrier proteins that incorporate the polar amino acid …

Lentiviral vectors (LVs) have provided an efficient way to integrate our gene of interest into
eukaryote cells. Human immunodeficiency virus (HIV)-derived LVs have been vastly studied …

The evolutionary conflict between retroviruses and their vertebrate hosts over millions of
years has led to the emergence of cellular innate immune proteins termed restriction factors …

Members of the serine incorporator (SERINC) protein family exert broad antiviral activity,
and many viruses encode SERINC antagonists to circumvent these restrictions. Significant …

Tetherin is a host defense factor that physically prevents virion release from the plasma
membrane. The Nef accessory protein of simian immunodeficiency virus (SIV) engages the …

Serine incorporator 3 (SERINC3) and SERINC5 were recently identified as host intrinsic
factors against human immunodeficiency virus (HIV)-1 and counteracted by HIV-1 Nef …