Intrinsic optical signal (IOS) imaging promises to be a noninvasive method for high-
resolution examination of retinal physiology, which can advance the study and diagnosis of …

Age-related macular degeneration (AMD) is the leading cause of severe vision loss and
legal blindness. It is known that retinal photoreceptors are the primary target of AMD …

Functional mapping of photoreceptor physiology is important for better disease diagnosis
and treatment assessment. Fast intrinsic optical signal (IOS), which arises before light …

Quantitative evaluation of retinal neurovascular coupling is essential for a better
understanding of visual function and early detection of eye diseases. However, there is no …

Intrinsic optical signal (IOS) imaging of the retina, also termed as optoretinogram or
optoretinography (ORG), promises a non-invasive method for the objective assessment of …

Purpose: This study was designed to verify light-induced outer segment (OS) length
shrinkage of rod photoreceptors and to characterize its anatomic source at disc-level …

Stiles–Crawford effect (SCE) is exclusively observed in cone photoreceptors, but why the
SCE is absent in rod photoreceptors is still a mystery. In this study, we employed dynamic …

Intrinsic optical signal (IOS) imaging promises a noninvasive method for advanced study
and diagnosis of eye diseases. Before pursuing clinical applications, it is essential to …

Purpose.: The purposes of this study were to investigate the physiological mechanism of
stimulus-evoked fast intrinsic optical signals (IOSs) recorded in dynamic confocal imaging of …

This research aims to investigate the potential of using intrinsic optical signal (IOS)
optoretinography (ORG) to objectively detect dark adaptation (DA) abnormalities related to …