The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid
compliment of an organism, exists in eukaryotic microbes, several normal human tissues …

Most cancers exhibit aneuploidy, but its functional significance in tumor development is
controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using …

Chromosomal instability (CIN) is associated with many human diseases, including
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …

Despite significant advances in cancer diagnostics and therapeutics the majority of cancer
unfortunately remains incurable, which has led to continued research to better understand …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

The capability of cancer cells to manage stress induced by hypoxia, nutrient shortage,
acidosis, redox imbalance, loss of calcium homeostasis and exposure to drugs is a key …

Genomic instability is a hallmark of cancer and a common feature of human disorders,
characterized by growth defects, neurodegeneration, cancer predisposition, and aging …

Aneuploidy is frequently detected in early human embryos as a major cause of early
pregnancy failure. However, how aneuploidy affects cellular function remains elusive. Here …

Cancer cells are addicted to numerous non-oncogenic traits that enable them to thrive.
Proteotoxic stress is one such non-oncogenic trait that is experienced by all tumor cells …