Advances in Toxoplasma gondii Vaccines: Current Strategies and Challenges for Vaccine Development

KB Chu, FS Quan - Vaccines, 2021 - mdpi.com
Toxoplasmosis, caused by the apicomplexan parasite Toxoplasma gondii, is one of the most
damaging parasite-borne zoonotic diseases of global importance. While approximately one …

How does toxoplasmosis affect the maternal‐foetal immune interface and pregnancy?

M Borges, T Magalhães Silva, C Brito… - Parasite …, 2019 - Wiley Online Library
Toxoplasma gondii is a zoonotic parasite which, depending on the geographical location,
can infect between 10% and 90% of humans. Infection during pregnancy may result in …

Relevance of peroxiredoxins in pathogenic microorganisms

MA de Oliveira, CA Tairum, LES Netto… - Applied Microbiology …, 2021 - Springer
The oxidative and nitrosative responses generated by animals and plants are important
defenses against infection and establishment of pathogenic microorganisms such as …

LPS-mediated activation of TLR4 controls Toxoplasma gondii growth in human trophoblast cell (BeWo) and human villous explants in a dependent-manner of TRIF …

AM Rosini, SC Teixeira, ICB Milian, RJ Silva… - Tissue and Cell, 2022 - Elsevier
We evaluated the influence of the Toll-like receptor (TLR)-4 pathways on BeWo, JEG-3 and
HTR-8/SVneo cells, as well as in human villous explants infected with Toxoplasma gondii …

Biogenic silver nanoparticles (AgNp-Bio) reduce Toxoplasma gondii infection and proliferation in HeLa cells, and induce autophagy and death of tachyzoites by …

RA da Silva Sanfelice, BT da Silva Bortoleti… - Acta Tropica, 2021 - Elsevier
Toxoplasma gondii is a protozoan parasite that can cause severe and debilitating diseases,
especially in immunocompromised individuals. The available treatment is based on drugs …

Neospora GRA6 possesses immune-stimulating activity and confers efficient protection against Neospora caninum infection in mice

RM Fereig, N Shimoda, HH Abdelbaky, Y Kuroda… - Veterinary …, 2019 - Elsevier
Vaccination has the potential to be the most cost-effective control measure for reducing the
economic burden of neosporosis in cattle. In this study, the immune-stimulatory effect of …

Comparative Evaluation of Four Potent Neospora caninum Diagnostic Antigens Using Immunochromatographic Assay for Detection of Specific Antibody in Cattle

RM Fereig, HH Abdelbaky, Y Nishikawa - Microorganisms, 2021 - mdpi.com
Neospora caninum is an intracellular protozoan parasite responsible for numerous abortion
outbreaks and neonatal abnormalities in cattle. Rapid and accurate diagnosis is critical for …

Protective efficacy of recombinant Toxoplasma gondii dense granule protein 15 against toxoplasmosis in C57BL/6 mice

T Hasan, N Shimoda, S Nakamura, BA Fox, DJ Bzik… - Vaccine, 2024 - Elsevier
Toxoplasma gondii is a pervasive protozoan parasite that is responsible for significant
zoonoses. A wide array of vaccines using different effector molecules of T. gondii have been …

Exploiting the Macrophage Production of IL-12 in Improvement of Vaccine Development against Toxoplasma gondii and Neospora caninum Infections

RM Fereig, MA Omar, AF Alsayeqh - Vaccines, 2022 - mdpi.com
Toxoplasmosis and neosporosis are major protozoan diseases of global distribution.
Toxoplasma gondii is the cause of toxoplasmosis, which affects almost all warm-blooded …

Evaluation of the immune response against Trypanosoma cruzi cytosolic tryparedoxin peroxidase in human natural infection

MC Girard, GR Acevedo, L López, MS Ossowski… - …, 2018 - Wiley Online Library
Trypanosoma cruzi, the aetiological agent of Chagas disease, has a highly efficient
detoxification system to deal with the oxidative burst imposed by its host. One of the …