[HTML][HTML] Mechanistic concepts of iron-sulfur protein biogenesis in Biology

JJ Braymer, SA Freibert, M Rakwalska-Bange… - Biochimica et Biophysica …, 2021 - Elsevier
Abstract Iron-sulfur (Fe/S) proteins are present in virtually all living organisms and are
involved in numerous cellular processes such as respiration, photosynthesis, metabolic …

The elemental role of iron in DNA synthesis and repair

S Puig, L Ramos-Alonso, AM Romero… - Metallomics, 2017 - academic.oup.com
Iron is an essential redox element that functions as a cofactor in many metabolic pathways.
Critical enzymes in DNA metabolism, including multiple DNA repair enzymes (helicases …

Iron–sulfur clusters as inhibitors and catalysts of viral replication

K Honarmand Ebrahimi, S Ciofi-Baffoni… - Nature Chemistry, 2022 - nature.com
A virus hijacks host cellular machineries and metabolites in order to reproduce. In response,
the innate immune system activates different processes to fight back. Although many aspects …

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources

SR Engel, ED Wong, RS Nash, S Aleksander… - Genetics, 2022 - academic.oup.com
Saccharomyces cerevisiae is used to provide fundamental understanding of eukaryotic
genetics, gene product function, and cellular biological processes. Saccharomyces Genome …

CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication

F Rehfeld, JL Eitson, MB Ohlson, TC Chang… - Cell Reports, 2023 - cell.com
During translation of the genomic RNA of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the causative virus in the COVID-19 pandemic, host ribosomes undergo …

Protein networks in the maturation of human iron–sulfur proteins

S Ciofi-Baffoni, V Nasta, L Banci - Metallomics, 2018 - academic.oup.com
The biogenesis of iron–sulfur (Fe–S) proteins in humans is a multistage process occurring in
different cellular compartments. The mitochondrial iron–sulfur cluster (ISC) assembly …

Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins

MA Uzarska, V Nasta, BD Weiler, F Spantgar… - Elife, 2016 - elifesciences.org
Assembly of mitochondrial iron-sulfur (Fe/S) proteins is a key process of cells, and defects
cause many rare diseases. In the first phase of this pathway, ten Fe/S cluster (ISC) assembly …

From the discovery to molecular understanding of cellular iron-sulfur protein biogenesis

R Lill - Biological chemistry, 2020 - degruyter.com
Protein cofactors often are the business ends of proteins, and are either synthesized inside
cells or are taken up from the nutrition. A cofactor that strictly needs to be synthesized by …

On the origin of iron/sulfur cluster biosynthesis in eukaryotes

AD Tsaousis - Frontiers in microbiology, 2019 - frontiersin.org
Iron and sulfur are indispensable elements of every living cell, but on their own these
elements are toxic and require dedicated machineries for the formation of iron/sulfur (Fe/S) …

Cytosolic iron–sulfur protein assembly system identifies clients by a C-terminal tripeptide

MD Marquez, C Greth, A Buzuk, Y Liu… - Proceedings of the …, 2023 - National Acad Sciences
The eukaryotic cytosolic Fe–S protein assembly (CIA) machinery inserts iron–sulfur (Fe–S)
clusters into cytosolic and nuclear proteins. In the final maturation step, the Fe–S cluster is …