Simultaneous widefield voltage and dye-free optical mapping quantifies electromechanical waves in human induced pluripotent stem cell-derived cardiomyocytes

W Liu, JL Han, J Tomek, G Bub, E Entcheva - ACS photonics, 2023 - ACS Publications
Coupled electromechanical waves define a heart's function in health and diseases. Optical
mapping of electrical waves using fluorescent labels offers mechanistic insights into cardiac …

Reconstructing in-depth activity for chaotic 3D spatiotemporal excitable media models based on surface data

R Stenger, S Herzog, I Kottlarz, B Rüchardt… - … Journal of Nonlinear …, 2023 - pubs.aip.org
Motivated by potential applications in cardiac research, we consider the task of
reconstructing the dynamics within a spatiotemporal chaotic 3D excitable medium from …

Reconstruction of three-dimensional scroll waves in excitable media from two-dimensional observations using deep neural networks

J Lebert, M Mittal, J Christoph - Physical Review E, 2023 - APS
Scroll wave dynamics are thought to underlie life-threatening ventricular fibrillation.
However, direct observations of three-dimensional electrical scroll waves remain elusive, as …

Synchronization of spatiotemporal chaos and reservoir computing via scalar signals

X Chen, T Weng, H Yang - Chaos, Solitons & Fractals, 2023 - Elsevier
Reservoir computing turns out to be a powerful data-driven tool for model-free prediction
and synchronization of chaotic systems. However, recent studies of synchronization using …

Reconstruction of excitation waves from mechanical deformation using physics-informed neural networks

N Dermul, H Dierckx - Scientific Reports, 2024 - nature.com
Non-invasive assessment of the electrical activation pattern can significantly contribute to
the diagnosis and treatment of cardiac arrhythmias, due to faster and safer diagnosis …

Spatiotemporal organization of electromechanical phase singularities during high-frequency cardiac arrhythmias

A Molavi Tabrizi, A Mesgarnejad, M Bazzi, S Luther… - Physical Review X, 2022 - APS
Ventricular fibrillation (VF) is a life-threatening electromechanical dysfunction of the heart
associated with complex spatiotemporal dynamics of electrical excitation and mechanical …

Pacemaking function of two simplified cell models

M Ryzhii, E Ryzhii - Plos one, 2022 - journals.plos.org
Simplified nonlinear models of biological cells are widely used in computational
electrophysiology. The models reproduce qualitatively many of the characteristics of various …

[HTML][HTML] Inverse mechano-electrical reconstruction of cardiac excitation wave patterns from mechanical deformation using deep learning

J Christoph, J Lebert - Chaos: An Interdisciplinary Journal of Nonlinear …, 2020 - pubs.aip.org
The inverse mechano-electrical problem in cardiac electrophysiology is the attempt to
reconstruct electrical excitation or action potential wave patterns from the heart's mechanical …

Panoramic Voltage-Sensitive Optical Mapping of Contracting Hearts using Cooperative Multi-View Motion Tracking with 12 to 24 Cameras

S Chowdhary, J Lebert, S Dickman… - arXiv preprint arXiv …, 2023 - arxiv.org
Action potential waves triggering the heart's contractions can be imaged at high spatial and
temporal resolutions across the heart surface using voltage-sensitive optical mapping …

Reconstructing complex cardiac excitation waves from incomplete data using echo state networks and convolutional autoencoders

S Herzog, RS Zimmermann, J Abele… - Frontiers in Applied …, 2021 - frontiersin.org
The mechanical contraction of the pumping heart is driven by electrical excitation waves
running across the heart muscle due to the excitable electrophysiology of heart cells. With …