Chronic stressful life events are risk factors for developing major depression, the
pathophysiology of which is strongly linked to impairments in serotonin (5-HT) …

Childhood trauma is a potent risk factor for developing depression in adulthood, particularly
in response to additional stress. We here summarize results from a series of clinical studies …

Due to the clinical and etiological heterogeneity of major depressive disorder, it has been
difficult to elucidate its pathophysiology. Current neurobiological theories with the most valid …

This review discusses neurobiological and psychosocial factors associated with stress-
induced depression and compares these factors with those believed to characterize stress …

OBJECTIVE: To review critically the past 10 years of research on youth suicide. METHOD:
Research literature on youth suicide was reviewed following a systematic search of …

An essential component of the human diet, L-tryptophan is critical in a number of metabolic
functions and has been widely used in numerous research and clinical trials. This review …

When planning a series of actions, it is usually infeasible to consider all potential future
sequences; instead, one must prune the decision tree. Provably optimal pruning is, however …

The limited success of genetic studies of major depression has raised questions concerning
the definition of genetically relevant phenotypes. This paper presents strategies to improve …

Dysfunction in the monoamine systems of serotonin (5-HT), norepinephrine (NE) and
dopamine (DA) may causally be related to major depressive disorder (MDD). Monoamine …

Background Functional imaging studies of major depressive disorder demonstrate response-
specific regional changes following various modes of antidepressant treatment. Objective To …