Atherosclerosis underlies the predominant number of cardiovascular diseases and remains
a leading cause of morbidity and mortality worldwide. The development, progression and …

Cardiometabolic and vascular disease, with their associated secondary complications, are
the leading cause of morbidity and mortality in Western society. Chronic inflammation is a …

Background: Chronic activation of the innate immune system drives inflammation and
contributes directly to atherosclerosis. We previously showed that macrophages in the …

Objective—During inflammation, macrophages secrete vesicles carrying RNA, protein, and
lipids as a form of extracellular communication. In the vessel wall, extracellular vesicles …

Atherosclerosis treatments by gene regulation are garnering attention, yet delivery of gene
cargoes to atherosclerotic plaques remains inefficient. Here, we demonstrate that assembly …

Clinical therapy of doxorubicin (DOX) is limited due to its cardiotoxicity. miR-146a was
proved as a protective factor in many cardiovascular diseases, but its role in chronic DOX …

Sortilin has been positively correlated with vascular disorders in humans. No study has yet
evaluated the possible direct effect of sortilin on vascular function. We used pharmacological …

Periodontitis, an oral chronic inflammatory disease, is reported to show an association with
atherosclerotic vascular disease. Fusobacterium nucleatum is an oral commensal bacterium …

Background: Acute lung injury (ALI) is a type of severe pulmonary inflammatory disease with
high rates of morbidity and mortality. Now, an increasing number of studies suggest that …

Extracellular vesicles (EVs) represent an emerging mechanism of cell–cell communication
in the cardiovascular system. Recent data suggest that EVs are produced and taken up by …