Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional
groups to explore and understand biology in living organisms. In this review, we summarize …

Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Bioorthogonal catalysis mediated by transition metals has inspired a new subfield of artificial
chemistry complementary to enzymatic reactions, enabling the selective labelling of …

Maximization of phototoxic damage on tumor with minimized side effect on normal tissue is
essential for effective anticancer photodynamic therapy (PDT). This requires highly cancer …

Propargylamines are a versatile class of compounds which find broad application in many
fields of chemistry. This review aims to describe the different strategies developed so far for …

The transformational impact of bioorthogonal chemistries has inspired new strategies for the
in vivo synthesis of bioactive agents through non-natural means. Among these, Pd catalysts …

Bioorthogonal transformations are chemical reactions that use pathways which biological
processes do not access. Bioorthogonal chemistry provides new approaches for imaging …

CuAAC chemistry is used to compose incredible synthetic molecular architectures and acts
as a true click chemistry reaction allowing densely functional molecular fragments to be …

As one of the typical bioorthogonal reactions, copper (I)-catalyzed azide-alkyne
cycloaddition (CuAAC) reaction holds great potential in organic synthesis, bioconjugation …

Introduction: Click chemistry has been exploited widely in the past to expedite lead
discovery and optimization. Indeed, Copper-catalyzed azide-alkyne cycloaddition (CuAAC) …