Purpose: The primary objective was to evaluate intracranial objective response rate (iORR)
in patients receiving abemaciclib with brain or leptomeningeal metastases (LM) secondary …

Perillyl alcohol (POH) is a naturally occurring monoterpenoid related to limonene that is
present in the essential oils of various plants. It has diverse applications and can be found in …

Breast cancer (BC) brain metastases is a life-threatening condition to which accounts the
poor understanding of BC cells'(BCCs) extravasation into the brain, precluding the …

Background The antitumor efficacy of human epidermal growth factor receptor 2 (HER2)-
targeted therapies, such as humanized monoclonal antibody trastuzumab (Herceptin® …

Improvements in the diagnosis and treatment of systemic breast cancer have led to a
prolongation in patient survival. Unfortunately, these advances are also associated with an …

Breast cancer (BC) is the most commonly diagnosed cancer worldwide. Advanced BC with
brain metastasis (BM) is a major cause of mortality with no specific or effective treatment …

OBJECTIVE Immune checkpoint-inhibitory therapeutic antibodies have shown striking
activity against several types of cancers but are less effective against brain-localized …

HER2-positive breast cancer accounts for 15–20% in breast cancer and 50% of the
metastatic HER2-positive breast cancer patients died of central nervous system progression …

Endocrine resistant breast cancer metastasis continues to serve as a significant clinical
challenge with high morbidity and mortality for patients. As the number of breast cancer …

Background Brain metastasis from breast cancer (BC) is an important cause of BC-related
death. The present study aimed to identify markers of brain metastasis from BC. Methods …