Autophagy and autophagy-related pathways in cancer
Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …
Impact of context-dependent autophagy states on tumor progression
M Assi, AC Kimmelman - Nature cancer, 2023 - nature.com
Macroautophagy is a cellular quality-control process that degrades proteins, protein
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …
Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth
M Yuan, B Tu, H Li, H Pang, N Zhang, M Fan, J Bai… - Nature cancer, 2022 - nature.com
Cancer-associated fibroblasts (CAFs) are one of the most prominent and active components
in the pancreatic tumor microenvironment. Our data show that CAFs are critical for survival …
in the pancreatic tumor microenvironment. Our data show that CAFs are critical for survival …
Recent advances in targeting autophagy in cancer
Autophagy is a cellular homeostasis mechanism that fuels the proliferation and survival of
advanced cancers by degrading and recycling organelles and proteins. Preclinical studies …
advanced cancers by degrading and recycling organelles and proteins. Preclinical studies …
Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesis
J Bai, T Liu, B Tu, M Yuan, Z Shu, M Fan, S Huo… - Autophagy, 2023 - Taylor & Francis
Cancer-associated fibroblasts (CAFs) are considered one of the most critical stromal cells
that interact with pancreatic ductal adenocarcinoma (PDAC) and promote tumor growth …
that interact with pancreatic ductal adenocarcinoma (PDAC) and promote tumor growth …
[HTML][HTML] Targeting the tumor microenvironment: Potential strategy for cancer therapeutics
Q Babar, A Saeed, TA Tabish, M Sarwar… - Biochimica et Biophysica …, 2023 - Elsevier
Cellular and stromal components including tumor cells, immune cells, mesenchymal cells,
cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment …
cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment …
Chemotherapy as a regulator of extracellular matrix-cell communication: Implications in therapy resistance
J Gonzalez-Molina, L Moyano-Galceran… - Seminars in Cancer …, 2022 - Elsevier
The development of most solid cancers, including pancreatic, breast, lung, liver, and ovarian
cancer, involves a desmoplastic reaction: a process of major remodeling of the extracellular …
cancer, involves a desmoplastic reaction: a process of major remodeling of the extracellular …
Regulation of autophagy fires up the cold tumor microenvironment to improve cancer immunotherapy
Z Jin, X Sun, Y Wang, C Zhou, H Yang… - Frontiers in …, 2022 - frontiersin.org
Immunotherapies, such as immune checkpoint inhibitors (ICIs) and chimeric antigen
receptor (CAR) T cells, have revolutionized the treatment of patients with advanced and …
receptor (CAR) T cells, have revolutionized the treatment of patients with advanced and …
Extracellular matrix remodeling facilitates obesity-associated cancer progression
M Kim, C Lee, J Park - Trends in cell biology, 2022 - cell.com
Obesity, a global public health concern, is an important risk factor for metabolic diseases
and several cancers. Fibro-inflammation in adipose tissues (ATs) is tightly associated with …
and several cancers. Fibro-inflammation in adipose tissues (ATs) is tightly associated with …
Canonical and non-canonical roles for ATG8 proteins in autophagy and beyond
SE Reid, SP Kolapalli, TM Nielsen… - Frontiers in Molecular …, 2022 - frontiersin.org
During autophagy, the ATG8 family proteins have several well-characterized roles in
facilitating early, mid, and late steps of autophagy, including autophagosome expansion …
facilitating early, mid, and late steps of autophagy, including autophagosome expansion …