Renin-angiotensin system blockers and the COVID-19 pandemic: at present there is no evidence to abandon renin-angiotensin system blockers

AHJ Danser, M Epstein, D Batlle - Hypertension, 2020 - Am Heart Assoc
During the spread of the severe acute respiratory syndrome coronavirus-2, some reports of
data still emerging and in need of full analysis indicate that certain groups of patients are at …

Interaction of SARS-CoV-2 and other coronavirus with ACE (angiotensin-converting enzyme)-2 as their main receptor: therapeutic implications

AM Davidson, J Wysocki, D Batlle - Hypertension, 2020 - Am Heart Assoc
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 originated from Wuhan,
China, in December 2019 and rapidly spread to other areas worldwide. Since then …

Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19

G Li, X He, L Zhang, Q Ran, J Wang, A Xiong… - Journal of …, 2020 - Elsevier
It has been reported that SARS-CoV-2 may use ACE2 as a receptor to gain entry into human
cells, in a way similar to that of SARS-CoV. Analyzing the distribution and expression level of …

A time-resolved proteomic and prognostic map of COVID-19

V Demichev, P Tober-Lau, O Lemke, T Nazarenko… - Cell systems, 2021 - cell.com
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection
to severe organ damage and death. We characterized the time-dependent progression of …

Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies

S Patel, A Rauf, H Khan, T Abu-Izneid - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Renin-angiotensin-aldosterone system (RAAS) is a vital system of human body, as it
maintains plasma sodium concentration, arterial blood pressure and extracellular volume …

ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities–role of gut microbiota dysbiosis

SD Viana, S Nunes, F Reis - Ageing research reviews, 2020 - Elsevier
Abstract Coronavirus disease 19 (COVID-19) is a pandemic condition caused by the new
coronavirus SARS-CoV-2. The typical symptoms are fever, cough, shortness of breath …

Characterization of ACE and ACE2 expression within different organs of the NOD mouse

H Roca-Ho, M Riera, V Palau, J Pascual… - International journal of …, 2017 - mdpi.com
Renin angiotensin system (RAS) is known to play a key role in several diseases such as
diabetes, and renal and cardiovascular pathologies. Its blockade has been demonstrated to …

Downregulation of ACE2 induces overstimulation of the renin–angiotensin system in COVID-19: should we block the renin–angiotensin system?

F Silhol, G Sarlon, JC Deharo, B Vaïsse - Hypertension Research, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 is the cause of the ongoing coronavirus
disease-19 (COVID-19) pandemic. Mortality is mainly due to acute respiratory distress …

A novel soluble ACE2 variant with prolonged duration of action neutralizes SARS-CoV-2 infection in human kidney organoids

J Wysocki, M Ye, L Hassler, AK Gupta… - Journal of the …, 2021 - journals.lww.com
Background There is an urgent need for approaches to prevent and treat SARS-CoV-2
infection. Administration of soluble ACE2 protein acting as a decoy to bind to SARS-CoV-2 …

[HTML][HTML] ACE2–From the renin–angiotensin system to gut microbiota and malnutrition

T Perlot, JM Penninger - Microbes and infection, 2013 - Elsevier
The renin–angiotensin system (RAS) is a complex network that regulates blood pressure,
electrolyte and fluid homeostasis, as well as the function of several organs. Angiotensin …