The Role of Sodium-Glucose Cotransporter-2 Inhibitors in Heart Failure Management: The Continuing Challenge of Clinical Outcome Endpoints in Heart Failure Trials

L Ji, M Mishra, B De Geest - Pharmaceutics, 2023 - mdpi.com
The introduction of sodium-glucose cotransporter-2 (SGLT2) inhibitors in the management of
heart failure with preserved ejection fraction (HFpEF) may be regarded as the first effective …

The SLC9C2 Gene Product (Na+/H+ Exchanger Isoform 11; NHE11) Is a Testis-Specific Protein Localized to the Head of Mature Mammalian Sperm

CC Gardner, PF James - International Journal of Molecular Sciences, 2023 - mdpi.com
Na+/H+ exchangers (NHEs) are a family of ion transporters that regulate the pH of various
cell compartments across an array of cell types. In eukaryotes, NHEs are encoded by the …

Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors: Guardians against Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Heart Diseases

LTT Pham, S Mangmool… - ACS Pharmacology & …, 2024 - ACS Publications
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an innovative class of antidiabetic
drugs that provide cardiovascular benefits to both diabetic and nondiabetic patients …

pH Homeodynamics and Male Fertility: A Coordinated Regulation of Acid-Based Balance during Sperm Journey to Fertilization

P Dai, M Zou, Z Cai, X Zeng, X Zhang, M Liang - Biomolecules, 2024 - mdpi.com
pH homeostasis is crucial for spermatogenesis, sperm maturation, sperm physiological
function, and fertilization in mammals. HCO3− and H+ are the most significant factors …

Ion channel trafficking implications in heart failure

JB Reisqs, YS Qu, M Boutjdir - Frontiers in Cardiovascular Medicine, 2024 - frontiersin.org
Heart failure (HF) is recognized as an epidemic in the contemporary world, impacting
around 1%–2% of the adult population and affecting around 6 million Americans. HF …