[HTML][HTML] Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and …
Interactions of malignant multiple myeloma (MM) plasma cells with the microenvironment
control MM plasma-cell growth, survival, drug-resistance and dissemination. As …
control MM plasma-cell growth, survival, drug-resistance and dissemination. As …
The multi-omics single-cell landscape of sinus mucosa in uncontrolled severe chronic rhinosinusitis with nasal polyps
Uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with
elevated levels of type 2 inflammatory cytokines and raised immunoglobulin concentrations …
elevated levels of type 2 inflammatory cytokines and raised immunoglobulin concentrations …
[HTML][HTML] Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the
mechanism generating their diversity remains elusive. We performed single-cell RNA …
mechanism generating their diversity remains elusive. We performed single-cell RNA …
High‐Throughput Cellular Heterogeneity Analysis in Cell Migration at the Single‐Cell Level
Cancer cell migration represents an essential step toward metastasis and cancer deaths.
However, conventional drug discovery focuses on cytotoxic and growth‐inhibiting …
However, conventional drug discovery focuses on cytotoxic and growth‐inhibiting …
PTTG1 is involved in TNF‐α‐related hepatocellular carcinoma via the induction of c‐myc
X Lin, Y Yang, Y Guo, H Liu, J Jiang, F Zheng… - Cancer …, 2019 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a malignant disease caused by a variety of factors.
However, the genomic and molecular aberrations in HCC are largely unknown. Herein …
However, the genomic and molecular aberrations in HCC are largely unknown. Herein …
[HTML][HTML] Oleate acid-stimulated HMMR expression by CEBPα is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma
D Zhang, J Liu, T Xie, Q Jiang, L Ding… - International Journal of …, 2020 - ncbi.nlm.nih.gov
Non-alcoholic steatohepatitis (NASH) is a type of nonalcoholic fatty liver disease and has
become a major risk factor for hepatocellular carcinoma (HCC). However, the underlying …
become a major risk factor for hepatocellular carcinoma (HCC). However, the underlying …
Twist-1 is upregulated by NSD2 and contributes to tumour dissemination and an epithelial-mesenchymal transition-like gene expression signature in t (4; 14)-positive …
Approximately 15% of patients with multiple myeloma (MM) harbour the t (4; 14)
chromosomal translocation, leading to the overexpression of the histone methyltransferase …
chromosomal translocation, leading to the overexpression of the histone methyltransferase …
The clinical value and biological function of PTTG1 in colorectal cancer
Q Ren, B Jin - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Pituitary tumor transforming gene-1 (PTTG1) has been suggested to serve as an oncogene
in several types of human tumors, but little is known about the biological function of PTTG1 …
in several types of human tumors, but little is known about the biological function of PTTG1 …
[HTML][HTML] Gene signatures and prognostic analyses of the Tob/BTG pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients
Breast cancer is the most common cancer type in females, and exploring the mechanisms of
disease progression is playing a crucial role in the development of potential therapeutics …
disease progression is playing a crucial role in the development of potential therapeutics …
[HTML][HTML] Neural progenitor fate decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice
The development of the cerebral cortex is a tightly regulated process that relies on
exquisitely coordinated actions of intrinsic and extrinsic cues. Here, we show that the …
exquisitely coordinated actions of intrinsic and extrinsic cues. Here, we show that the …