Increasing sophistication in molecular-replacement (MR) software and the rapid expansion
of the PDB in recent years have allowed the technique to become the dominant method for …

Paramyxoviruses are enveloped, nonsegmented, negative-strand RNA viruses that cause a
wide spectrum of human and animal diseases. The viral genome, packaged by the …

In late 2020, the results of CASP14, the 14th event in a series of competitions to assess the
latest developments in computational protein structure-prediction methodology, revealed the …

ARCIMBOLDO solves the phase problem at resolutions of around 2 Å or better through
massive combination of small fragments and density modification. For complex structures …

ARCIMBOLDO solves the phase problem by combining the location of small model
fragments using Phaser with density modification and autotracing using SHELXE. Mainly …

Crystallographers have an array of search-model options for structure solution by molecular
replacement (MR). The well established options of homologous experimental structures and …

The prokaryotic chemotaxis system is arguably the best-understood signaling pathway in
biology. In all previously described species, chemoreceptors organize into a hexagonal (P6 …

Correctly positioning ideal protein fragments by molecular replacement presents an
attractive method for obtaining preliminary phases when no template structure for molecular …

Molecular replacement (MR) is the predominant route to solution of the phase problem in
macromolecular crystallography. Where the lack of a suitable homologue precludes …

Fragment-based molecular-replacement methods can solve a macromolecular structure
quasi-ab initio. ARCIMBOLDO, using a common secondary-structure or tertiary-structure …