The faithful execution of biological processes requires a precise and carefully orchestrated
set of steps that depend on the proper spatial and temporal expression of genes. Here we …

Locus control regions (LCRs) are operationally defined by their ability to enhance the
expression of linked genes to physiological levels in a tissue-specific and copy number …

Developmental gene expression is often controlled by distal regulatory DNA elements called
enhancers. Distant enhancer action is restricted to structural chromosomal domains that are …

Distal enhancers commonly contact target promoters via chromatin looping. In erythroid
cells, the locus control region (LCR) contacts β-type globin genes in a developmental stage …

The discovery of interchromosomal interactions in higher eukaryotes points to a functional
interplay between genome architecture and gene expression, challenging the view of …

Abstract Background Type II DNA topoisomerases (TOP2) regulate DNA topology by
generating transient double stranded breaks during replication and transcription …

The expression of a single odorant receptor (OR) gene from a large gene family in individual
sensory neurons is an essential feature of the organization and function of the olfactory …

Locus control regions (LCRs) are defined by their ability, in transgenic assays, to direct high-
level, tissue-specific expression of linked genes at all sites of integration examined and at …

Developmental and tissue-specific expression of higher eukaryotic genes involves activation
of transcription at the appropriate time and place and keeping it silent otherwise. Unlike …

In 1993, several groups, working independently, reported the successful generation of
transgenic mice with yeast artificial chromosomes (YACs) using standard techniques. The …