[HTML][HTML] Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions
M Yan, Y Huo, S Yin, H Hu - Redox biology, 2018 - Elsevier
Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in
many developed countries. Mitochondrial oxidative stress is considered to be the …
many developed countries. Mitochondrial oxidative stress is considered to be the …
Acetaminophen hepatotoxicity
A Ramachandran, H Jaeschke - Seminars in liver disease, 2019 - thieme-connect.com
Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …
However, due to its wide availability, it is frequently implicated in intentional or unintentional …
Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure
BL Woolbright, H Jaeschke - Journal of hepatology, 2017 - Elsevier
Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen
overdose is the number one cause of acute liver failure and remains a major problem in …
overdose is the number one cause of acute liver failure and remains a major problem in …
The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury
Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a
major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a …
major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a …
Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing
Current drug-safety assays for hepatotoxicity rely on biomarkers with low predictive power.
The production of radical species, specifically reactive oxygen species (ROS) and reactive …
The production of radical species, specifically reactive oxygen species (ROS) and reactive …
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose
Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-
acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 …
acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 …
[HTML][HTML] Acetaminophen toxicity: novel insights into mechanisms and future perspectives
A Ramachandran, H Jaeschke - Gene expression, 2018 - ncbi.nlm.nih.gov
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …
and decades of intense study of its pathogenesis resulted in the development of the antidote …
Acetaminophen: dose-dependent drug hepatotoxicity and acute liver failure in patients
H Jaeschke - Digestive Diseases, 2015 - karger.com
Background: Drug-induced liver injury is a rare but serious clinical problem. A number of
drugs can cause severe liver injury and acute liver failure at therapeutic doses in a very …
drugs can cause severe liver injury and acute liver failure at therapeutic doses in a very …
[HTML][HTML] Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at
therapeutic doses but can cause severe liver injury and even liver failure after overdoses …
therapeutic doses but can cause severe liver injury and even liver failure after overdoses …
[HTML][HTML] Acetaminophen-induced liver injury: from animal models to humans
Drug-induced liver injury is an important clinical problem and a challenge for drug
development. Whereas progress in understanding rare and unpredictable (idiosyncratic) …
development. Whereas progress in understanding rare and unpredictable (idiosyncratic) …