Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

Blood vessels are exposed to multiple mechanical forces that are exerted on the vessel wall
(radial, circumferential and longitudinal forces) or on the endothelial surface (shear stress) …

The density and architecture of capillary beds that form within a tissue depend on many
factors, including local metabolic demand and blood flow. Here, using microfluidic control of …

Endothelial cells throughout the body are heterogeneous, and this is tightly linked to the
specific functions of organs and tissues. Heterogeneity is already determined from …

Blood-vessel formation generates unique vascular patterns in each individual. The
principles governing the apparent stochasticity of this process remain to be elucidated …

Over the past 40 years, there has been a strong focus on the development of mathematical
models of angiogenesis, while developmental remodelling has received little such attention …

During embryogenesis, the musculoskeletal system develops while containing within itself a
force generator in the form of the musculature. This generator becomes functional relatively …

Blood vessel morphology is dictated by mechanical and biochemical cues. Flow-induced
shear stress and pericytes both play important roles, and they have previously been studied …

Favouring or thwarting the development of a vascular network is essential in fields as
diverse as oncology, cardiovascular disease or tissue engineering. As a result …