Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …

Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to
preserve life, with ocular survival, visual preservation and quality of life as secondary aims …

Retinoblastoma is the most frequent intraocular malignancy in children, originating from a
maturing cone precursor in the developing retina. Little is known on the molecular basis …

Retinoblastoma is a childhood retinal tumour that initiates in response to biallelic RB1
inactivation and loss of functional retinoblastoma (Rb) protein. Although Rb has diverse …

Retinoblastoma is a retinal cancer that is initiated in response to biallelic loss of RB1 in
almost all cases, together with other genetic/epigenetic changes culminating in the …

Retinoblastoma (Rb) is the most prevalent intraocular malignancy in children, with a
worldwide survival rate< 30%. We have developed a cancerous model of Rb in retinal …

Tumor-derived cell-free DNA (cfDNA) has biomarker potential; therefore, this study aimed to
identify cfDNA in the aqueous humor (AH) of retinoblastoma eyes and correlate somatic …

Retinoblastoma, the most common primary intraocular cancer of childhood, is a malignancy
arising in the developing retina. Tumor formation usually begins with mutation in both alleles …

This review presents current knowledge on the molecular biology of retinoblastoma (RB).
Retinoblastoma is an intraocular tumor with hereditary and sporadic forms. 8,000 new cases …

Retinoblastoma is the most common paediatric neoplasm of the retina, and one of the
earliest model of cancer genetics since the identification of the master tumour suppressor …