[HTML][HTML] Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

L Zhong, Y Li, L Xiong, W Wang, M Wu… - Signal transduction and …, 2021 - nature.com
Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

Design and challenges of sonodynamic therapy system for cancer theranostics: from equipment to sensitizers

Z Gong, Z Dai - Advanced Science, 2021 - Wiley Online Library
As a novel noninvasive therapeutic modality combining low‐intensity ultrasound and
sonosensitizers, sonodynamic therapy (SDT) is promising for clinical translation due to its …

Micro/nanoparticle‐augmented sonodynamic therapy (SDT): breaking the depth shallow of photoactivation

X Qian, Y Zheng, Y Chen - Advanced materials, 2016 - Wiley Online Library
The fast development of photoactivation for cancer treatment provides an efficient photo‐
therapeutic strategy for cancer treatment, but traditional photodynamic or photothermal …

pH-responsive polymer nanomaterials for tumor therapy

S Chu, X Shi, Y Tian, F Gao - Frontiers in oncology, 2022 - frontiersin.org
The complexity of the tumor microenvironment presents significant challenges to cancer
therapy, while providing opportunities for targeted drug delivery. Using characteristic signals …

Single-step assembly of DOX/ICG loaded lipid–polymer nanoparticles for highly effective chemo-photothermal combination therapy

M Zheng, C Yue, Y Ma, P Gong, P Zhao, C Zheng… - ACS …, 2013 - ACS Publications
A combination of chemotherapy and photothermal therapy has emerged as a promising
strategy for cancer therapy. To ensure the chemotherapeutic drug and photothermal agent …

An imagable and photothermal" Abraxane-like" nanodrug for combination cancer therapy to treat subcutaneous and metastatic breast tumors.

Q Chen, C Liang, C Wang, Z Liu - Advanced Materials (Deerfield …, 2014 - europepmc.org
A new" Abraxane-like" nanotheranostic formulation self-assembled from three clinically
approved agents, human serum albumin, paclitaxel, and indocyanine green, is developed …

Role of angiogenesis in tumor growth and metastasis

J Folkman - Seminars in oncology, 2002 - Elsevier
Angiogenesis is required for invasive tumor growth and metastasis and constitutes an
important point in the control of cancer progression. Its inhibition may be a valuable new …

Tumor response to radiotherapy regulated by endothelial cell apoptosis

M Garcia-Barros, F Paris, C Cordon-Cardo, D Lyden… - Science, 2003 - science.org
About 50% of cancer patients receive radiation therapy. Here we investigated the hypothesis
that tumor response to radiation is determined not only by tumor cell phenotype but also by …

Regulation of Mammalian O2 Homeostasis by Hypoxia-Inducible Factor 1

GL Semenza - Annual review of cell and developmental biology, 1999 - annualreviews.org
▪ Abstract Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic-helix-loop-helix-PAS
transcription factor consisting of HIF-1α and HIF-1β subunits. HIF-1α expression and HIF-1 …

The anti-angiogenic basis of metronomic chemotherapy

RS Kerbel, BA Kamen - Nature Reviews Cancer, 2004 - nature.com
In addition to proliferating cancer cells and various types of normal cells, such as those of
the bone marrow, conventional cytotoxic chemotherapeutics affect the endothelium of the …