Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …

Colorectal cancer (CRC) is one of the most common malignant tumor types occurring in the
digestive system. The incidence of CRC has exhibits yearly increases and the mortality rate …

Wnt signalling is essential for regulation of embryonic development and adult tissue
homeostasis,–, and aberrant Wnt signalling is frequently associated with cancers. Wnt …

Wnt signaling plays an essential role in the initiation and progression of various types of
cancer. Besides, the Wnt pathway components have been established as reliable …

The WNT (Wingless/Integrated) signaling pathway is implicated in various stages of
glioblastoma, which is an aggressive brain tumor for which therapeutic options are limited …

Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is
regulated by over 40 enzymes, targeting more than 1,000 substrates at over 3,000 sites …

Background WNT974 is a small molecule inhibitor of Wnt signaling that specifically inhibits
porcupine O-acyltransferase. This phase Ib dose-escalation study evaluated the maximum …

Aberrant Wnt signaling activation is frequently observed in many cancers. The mutation
acquisition of Wnt signaling leads to tumorigenesis, whereas the inhibition of Wnt signaling …

Background & Aims RNF43 is an E3 ubiquitin ligase that is recurrently mutated in pancreatic
ductal adenocarcinoma (PDAC) and precursor cystic neoplasms of the pancreas. The …

Wnt signaling regulates the balance between stemness and differentiation in multiple
tissues and in cancer. RNF43-mutant pancreatic cancers are dependent on Wnt production …