Background The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin),
receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1 …

Gastrulation controls the emergence of cellular diversity and axis patterning in the early
embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the …

Recent advances in human blastoids have opened new avenues for modeling early human
development and implantation. One limitation of our first protocol for human blastoid …

Following implantation, the human embryo undergoes major morphogenetic transformations
that establish the future body plan. While the molecular events underpinning this process …

Despite over 40 years following the first birth from medically assisted reproduction (MAR)
technologies, mechanisms underlying the key developmental events during the first 7 days …

The initiation of human pregnancy is marked by the implantation of an embryo into the
uterine environment; however, the underlying mechanisms remain largely elusive. To …

The epiblast is the source of all mammalian embryonic tissues and of pluripotent embryonic
stem cells. It differentiates alongside the primitive endoderm in a “salt and pepper” pattern …

Co-expression of chimeric switch receptors (CSRs) specific for PD-L1 improves the
antitumor effects of chimeric antigen receptor (CAR) T cells. However, the effects of trans …

For the past 40 years, the 14-day rule has governed and, by defining a clear boundary,
enabled embryo research and the clinical benefits derived from this. It has been both a piece …

Fibroblasts residing in the connective tissues constitute the stem cell niche, particularly in
organs such as skin. Although the effect of fibroblasts on stem cell niches and organ aging is …