The growth hormone receptor (GHR), although most well known for regulating growth, has
many other important biological functions including regulating metabolism and controlling …

In evolutionary terms, GH and intracellular STAT 5 signaling is a very old regulatory system.
Whereas insulin dominates periprandially, GH may be viewed as the primary anabolic …

A. Genetic, molecular, and transgenic models B. Human GH rhythms III. Neuropeptide
Regulation of the GH Axis: Somatostatin and GHRH

Body composition exhibits marked variations across the early human lifetime. The precise
physiological mechanisms that drive such developmental adaptations are difficult to …

GH plays a pivotal role in regulating body growth and development, which is modulated by
sex steroids. A close interplay between estrogen and GH leads to attainment of …

Obesity has become one of the most common medical problems in developed countries,
and this disorder is associated with high incidences of hypertension, dyslipidaemia …

Polycystic ovary syndrome (PCOS) is a common endocrinopathy occurring in reproductive-
age women. Hyperandrogenism, polycystic ovaries, chronic anovulation, and metabolic …

Growth hormone (GH) is a major regulator of growth, somatic development and body
composition. Sex steroids can act centrally by regulating GH secretion and peripherally …

Sleep plays an essential role in human life. While sleep is a state elicited by the brain, its
vital role reaches beyond maintaining brain health. Unhealthy sleeping habits have been …

Activation of the gonadotropic and somatotropic axes in puberty is marked by striking
amplification of pulsatile neurohormone secretion. In addition, each axis, as a whole …