History shows that metal-based drugs and remedies have been known and used since very
ancient times. For example, silver was employed in the treatment of wounds and ulcers …

Group 9 metal complexes based on iridium and rhodium have recently arisen as fascinating
potential alternatives to existing platinum and ruthenium metallodrugs. While long regarded …

Organometallic complexes containing ligands such as CO, carbenes, alkyls, phenyls, π-
bound alkynes, alkenes, cyclopentadienyls and arenes possess properties which have often …

There is an emerging interest in applying inorganic and organometallic transition metal
complexes to biomolecular and cellular studies. The cytotoxic effects of these complexes on …

Until recently, Rh (III) and particularly Ir (III) complexes were generally considered as being
unlikely candidates for anticancer agents owing to the typical kinetic inertness of their …

Since the discovery of cisplatin more than 40 years ago, enormous research efforts have
been dedicated to developing metal-based anticancer agents and to elucidating the …

We report the synthesis, characterization, and antiproliferative activity of 15 iridium (III) half-
sandwich complexes of the type [(η5-Cp*) Ir (2-(R′-phenyl)-R-pyridine) Cl] bearing either …

Metal complexes have been the subject of numerous investigations in oncology but, despite
the plethora of newly synthesized compounds, their precise mechanisms of action remain …

Several proteins and peptides have therapeutic potential and can be used for cancer
therapy. By binding to cell surface receptors and other indicators uniquely linked with or …

Platinum-based anticancer drugs are most likely the most successful group of bioinorganic
compounds. Their apparent disadvantages have led to the development of anticancer …