Epithelialization in wound healing: a comprehensive review

I Pastar, O Stojadinovic, NC Yin, H Ramirez… - Advances in wound …, 2014 - liebertpub.com
Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for
restoring the epidermis after injury through a process termed epithelialization. This review …

The role of TGFβ signaling in wound epithelialization

H Ramirez, SB Patel, I Pastar - Advances in wound care, 2014 - liebertpub.com
Significance: Transforming growth factor β (TGFβ) has a crucial role in maintaining skin
homeostasis. TGFβ signaling is important for re-epithelialization, inflammation …

[HTML][HTML] Staphylococcus aureus triggers induction of miR-15B-5P to diminish DNA repair and deregulate inflammatory response in diabetic foot ulcers

HA Ramirez, I Pastar, I Jozic, O Stojadinovic… - Journal of Investigative …, 2018 - Elsevier
Diabetic foot ulcers (DFUs) are a debilitating complication of diabetes in which bacterial
presence, including the frequent colonizer Staphylococcus aureus, contributes to inhibition …

Induction of specific microRNAs inhibits cutaneous wound healing

I Pastar, AA Khan, O Stojadinovic, EA Lebrun… - Journal of Biological …, 2012 - ASBMB
Chronic nonhealing wounds, such as venous ulcers (VUs), are a widespread and serious
medical problem with high morbidity and mortality. The molecular pathology of VUs remains …

Epigenetic regulation of cellular functions in wound healing

I Pastar, J Marjanovic, RC Stone, V Chen… - Experimental …, 2021 - Wiley Online Library
Stringent spatiotemporal regulation of the wound healing process involving multiple cell
types is associated with epigenetic mechanisms of gene regulation, such as DNA …

Descriptive vs mechanistic scientific approach to study wound healing and its inhibition: Is there a value of translational research involving human subjects?

I Pastar, LL Wong, AN Egger… - Experimental …, 2018 - Wiley Online Library
The clinical field of wound healing is challenged by numerous hurdles. Not only are wound‐
healing disorders complex and multifactorial, but the corresponding patient population is …

Comparative genomic, microRNA, and tissue analyses reveal subtle differences between non-diabetic and diabetic foot skin

HA Ramirez, L Liang, I Pastar, AM Rosa… - PloS one, 2015 - journals.plos.org
Diabetes Mellitus (DM) is a chronic, severe disease rapidly increasing in incidence and
prevalence and is associated with numerous complications. Patients with DM are at high risk …

The epigenetic regulation of wound healing

CJ Lewis, AN Mardaryev, AA Sharov… - Advances in wound …, 2014 - liebertpub.com
Significance: Epigenetic regulatory mechanisms are essential for epidermal homeostasis
and contribute to the pathogenesis of many skin diseases, including skin cancer and …

Barrier function of the repaired skin is disrupted following arrest of dicer in keratinocytes

S Ghatak, YC Chan, S Khanna, J Banerjee, J Weist… - Molecular Therapy, 2015 - cell.com
Tissue injury transiently silences miRNA-dependent posttranscriptional gene silencing in its
effort to unleash adult tissue repair. Once the wound is closed, miRNA biogenesis is induced …

Cellular reprogramming of diabetic foot ulcer fibroblasts triggers pro‐healing miRNA‐mediated epigenetic signature

I Pastar, J Marjanovic, L Liang, RC Stone… - Experimental …, 2021 - Wiley Online Library
Diabetic foot ulcers (DFUs), a prevalent complication of diabetes, constitute a major medical
challenge with a critical need for development of cell‐based therapies. We previously …