Epithelialization in wound healing: a comprehensive review
Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for
restoring the epidermis after injury through a process termed epithelialization. This review …
restoring the epidermis after injury through a process termed epithelialization. This review …
The role of TGFβ signaling in wound epithelialization
Significance: Transforming growth factor β (TGFβ) has a crucial role in maintaining skin
homeostasis. TGFβ signaling is important for re-epithelialization, inflammation …
homeostasis. TGFβ signaling is important for re-epithelialization, inflammation …
[HTML][HTML] Staphylococcus aureus triggers induction of miR-15B-5P to diminish DNA repair and deregulate inflammatory response in diabetic foot ulcers
Diabetic foot ulcers (DFUs) are a debilitating complication of diabetes in which bacterial
presence, including the frequent colonizer Staphylococcus aureus, contributes to inhibition …
presence, including the frequent colonizer Staphylococcus aureus, contributes to inhibition …
Induction of specific microRNAs inhibits cutaneous wound healing
Chronic nonhealing wounds, such as venous ulcers (VUs), are a widespread and serious
medical problem with high morbidity and mortality. The molecular pathology of VUs remains …
medical problem with high morbidity and mortality. The molecular pathology of VUs remains …
Epigenetic regulation of cellular functions in wound healing
Stringent spatiotemporal regulation of the wound healing process involving multiple cell
types is associated with epigenetic mechanisms of gene regulation, such as DNA …
types is associated with epigenetic mechanisms of gene regulation, such as DNA …
Descriptive vs mechanistic scientific approach to study wound healing and its inhibition: Is there a value of translational research involving human subjects?
I Pastar, LL Wong, AN Egger… - Experimental …, 2018 - Wiley Online Library
The clinical field of wound healing is challenged by numerous hurdles. Not only are wound‐
healing disorders complex and multifactorial, but the corresponding patient population is …
healing disorders complex and multifactorial, but the corresponding patient population is …
Comparative genomic, microRNA, and tissue analyses reveal subtle differences between non-diabetic and diabetic foot skin
HA Ramirez, L Liang, I Pastar, AM Rosa… - PloS one, 2015 - journals.plos.org
Diabetes Mellitus (DM) is a chronic, severe disease rapidly increasing in incidence and
prevalence and is associated with numerous complications. Patients with DM are at high risk …
prevalence and is associated with numerous complications. Patients with DM are at high risk …
The epigenetic regulation of wound healing
CJ Lewis, AN Mardaryev, AA Sharov… - Advances in wound …, 2014 - liebertpub.com
Significance: Epigenetic regulatory mechanisms are essential for epidermal homeostasis
and contribute to the pathogenesis of many skin diseases, including skin cancer and …
and contribute to the pathogenesis of many skin diseases, including skin cancer and …
Barrier function of the repaired skin is disrupted following arrest of dicer in keratinocytes
Tissue injury transiently silences miRNA-dependent posttranscriptional gene silencing in its
effort to unleash adult tissue repair. Once the wound is closed, miRNA biogenesis is induced …
effort to unleash adult tissue repair. Once the wound is closed, miRNA biogenesis is induced …
Cellular reprogramming of diabetic foot ulcer fibroblasts triggers pro‐healing miRNA‐mediated epigenetic signature
Diabetic foot ulcers (DFUs), a prevalent complication of diabetes, constitute a major medical
challenge with a critical need for development of cell‐based therapies. We previously …
challenge with a critical need for development of cell‐based therapies. We previously …