Population genomics of bacterial host adaptation

SK Sheppard, DS Guttman, JR Fitzgerald - Nature Reviews Genetics, 2018 - nature.com
Some bacteria can transfer to new host species, and this poses a risk to human health.
Indeed, an estimated 60% of all human pathogens have originated from other animal …

[HTML][HTML] One chromosome, one contig: complete microbial genomes from long-read sequencing and assembly

S Koren, AM Phillippy - Current opinion in microbiology, 2015 - Elsevier
Highlights•We describe three long-read sequencing technologies and their
characteristics.•We describe available algorithms for long-read assembly and their …

Rapid scoring of genes in microbial pan-genome-wide association studies with Scoary

O Brynildsrud, J Bohlin, L Scheffer, V Eldholm - Genome biology, 2016 - Springer
Genome-wide association studies (GWAS) have become indispensable in human medicine
and genomics, but very few have been carried out on bacteria. Here we introduce Scoary …

Reactive oxygen species are regulated by immune deficiency and Toll pathways in determining the host specificity of honeybee gut bacteria

L Guo, J Tang, M Tang, S Luo… - Proceedings of the …, 2023 - National Acad Sciences
Host specificity is observed in gut symbionts of diverse animal lineages. But how hosts
maintain symbionts while rejecting their close relatives remains elusive. We use eusocial …

[HTML][HTML] Host genetic regulation of human gut microbial structural variation

DV Zhernakova, D Wang, L Liu, S Andreu-Sánchez… - Nature, 2024 - nature.com
Although the impact of host genetics on gut microbial diversity and the abundance of specific
taxa is well established,,,,–, little is known about how host genetics regulates the genetic …

Twenty years of bacterial genome sequencing

NJ Loman, MJ Pallen - Nature Reviews Microbiology, 2015 - nature.com
Twenty years ago, the publication of the first bacterial genome sequence, from Haemophilus
influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades …

Microbial genome-wide association studies: lessons from human GWAS

RA Power, J Parkhill, T De Oliveira - Nature reviews genetics, 2017 - nature.com
The reduced costs of sequencing have led to whole-genome sequences for a large number
of microorganisms, enabling the application of microbial genome-wide association studies …

Pathogenomics of Emerging Campylobacter Species

D Costa, G Iraola - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Campylobacter is among the four main causes of gastroenteritis worldwide and has
increased in both developed and developing countries over the last 10 years. The vast …

Genome evolution and the emergence of pathogenicity in avian Escherichia coli

L Mageiros, G Méric, SC Bayliss, J Pensar… - Nature …, 2021 - nature.com
Chickens are the most common birds on Earth and colibacillosis is among the most common
diseases affecting them. This major threat to animal welfare and safe sustainable food …

Identifying lineage effects when controlling for population structure improves power in bacterial association studies

SG Earle, CH Wu, J Charlesworth, N Stoesser… - Nature …, 2016 - nature.com
Bacteria pose unique challenges for genome-wide association studies because of strong
structuring into distinct strains and substantial linkage disequilibrium across the genome 1 …