With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …

Cellular senescence is a plausible mediator of inflammation-related tissue dysfunction. In
the aged brain, senescent cell identities and the mechanisms by which they exert adverse …

Persistent low-grade inflammation and premature ageing are hallmarks of the uremic
phenotype and contribute to impaired health status, reduced quality of life, and premature …

Aging, an irreversible biological process, serves as an independent risk factor for chronic
disease including cancer, pulmonary, neurodegenerative, and cardiovascular diseases. In …

Adipose tissue as the largest energy reservoir and endocrine organ is essential for
maintenance of systemic glucose, lipid and energy homeostasis, but these metabolic …

Senescence is a state of permanent cell cycle arrest. Cellular senescence can promote
tissue remodelling but can negatively affect regenerative capacities of tissues and contribute …

Clinical radiotherapy treats life‐threatening cancers, but the radiation often affects
neighboring normal tissues including bone. Acute effects of ionizing radiation include …

Recent advances in health care have improved the management of cardiometabolic
disorders, and prolonged lifespan. However, the ever-rising prevalence of metabolic stress …