Metabolic engineering of Escherichia coli: a sustainable industrial platform for bio-based chemical production

X Chen, L Zhou, K Tian, A Kumar, S Singh… - Biotechnology …, 2013 - Elsevier
In order to decrease carbon emissions and negative environmental impacts of various
pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the …

Sustainable production of natural phenolics for functional food applications

R Mark, X Lyu, JJL Lee, R Parra-Saldívar… - Journal of Functional …, 2019 - Elsevier
Phenolics are a class of plant-derived natural secondary metabolites with good anticancer,
anti-inflammatory, antimicrobial and antioxidant activities. In addition to being natural health …

Combinatorial expression of bacterial whole mevalonate pathway for the production of β-carotene in E. coli

SH Yoon, SH Lee, A Das, HK Ryu, HJ Jang… - Journal of …, 2009 - Elsevier
The increased synthesis of building blocks of IPP (isopentenyl diphosphate) and DMAPP
(dimethylallyl diphosphate) through metabolic engineering is a way to enhance the …

Biosynthesis of coenzyme Q in eukaryotes

M Kawamukai - Bioscience, biotechnology, and biochemistry, 2016 - academic.oup.com
Coenzyme Q (CoQ) is a component of the electron transport chain that participates in
aerobic cellular respiration to produce ATP. In addition, CoQ acts as an electron acceptor in …

Metabolic engineering and synthetic biology approaches driving isoprenoid production in Escherichia coli

C Wang, B Zada, G Wei, SW Kim - Bioresource Technology, 2017 - Elsevier
Isoprenoids comprise the largest family of natural organic compounds with many useful
applications in the pharmaceutical, nutraceutical, and industrial fields. Rapid developments …

Cellular factories for coenzyme Q10 production

SQE Lee, TS Tan, M Kawamukai, ES Chen - Microbial cell factories, 2017 - Springer
Abstract Coenzyme Q 10 (CoQ 10), a benzoquinone present in most organisms, plays an
important role in the electron-transport chain, and its deficiency is associated with various …

Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway

C Wang, SH Yoon, AA Shah, YR Chung… - Biotechnology and …, 2010 - Wiley Online Library
Farnesol (FOH) production has been carried out in metabolically engineered Escherichia
coli. FOH is formed through the depyrophosphorylation of farnesyl pyrophosphate (FPP) …

4-Hydroxybenzoic acid—a versatile platform intermediate for value-added compounds

S Wang, M Bilal, H Hu, W Wang, X Zhang - Applied microbiology and …, 2018 - Springer
Hydroxybenzoic acid (4-HBA) has recently emerged as a promising intermediate for several
value-added bioproducts with potential biotechnological applications in food, cosmetics …

De novo production of the monoterpenoid geranic acid by metabolically engineered Pseudomonas putida

J Mi, D Becher, P Lubuta, S Dany, K Tusch… - Microbial cell …, 2014 - Springer
Background Production of monoterpenoids as valuable chemicals using recombinant
microbes is a growing field of interest. Unfortunately, antimicrobial activity of most …

Alternative metabolic pathways and strategies to high-titre terpenoid production in Escherichia coli

MA Rinaldi, CA Ferraz, NS Scrutton - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2021 Terpenoids are a diverse group of chemicals used in a wide range of
industries. Microbial terpenoid production has the potential to displace traditional …