Metabolic rewiring and the consequent production of reactive oxygen species (ROS) are
necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant …

Reactive oxygen or nitrogen species play an integral role in both myocardial injury and
repair. This dichotomy is differentiated at the level of species type, amount and duration of …

Intratumoral infiltration of myeloid-derived suppressor cells (MDSCs) is known to promote
neoplastic growth by inhibiting the tumoricidal activity of T cells. However, direct interactions …

Muscle differentiation is a crucial process controlling muscle development and homeostasis.
Mitochondrial reactive oxygen species (mtROS) rapidly increase and function as critical cell …

Macrophage infiltration contributes to the instability of atherosclerotic plaques. In the present
study, we investigated whether selective inhibition of PI3K/Akt/mTOR signaling pathway can …

The association of airborne particulate matter exposure with the deteriorating function of the
cardiovascular system is fundamentally driven by the impairment of mitochondrial-nuclear …

Abstract Significance: Metabolic syndrome (MetS) is associated with a greater risk of
diabetes and cardiovascular diseases. It is estimated that this multifactorial condition affects …

Astilbin (ASB), a dihydroflavonol glycoside, is widely found in a variety of plants and in
functional foods and acts as a powerful antioxidant. The aim of this study was to investigate …

Mitochondria are the main powerhouse of the cell, generating ATP through the tricarboxylic
acid cycle (TCA) and oxidative phosphorylation (OXPHOS), which drives myriad cellular …

Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the
elderly throughout the world. AMD is attributed to a complex interaction of genetic and …