Phosphoinositide 3-kinase/Akt signaling and redox metabolism in cancer
N Koundouros, G Poulogiannis - Frontiers in oncology, 2018 - frontiersin.org
Metabolic rewiring and the consequent production of reactive oxygen species (ROS) are
necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant …
necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant …
Oxidative stress and myocardial injury in the diabetic heart
DM Ansley, B Wang - The Journal of pathology, 2013 - Wiley Online Library
Reactive oxygen or nitrogen species play an integral role in both myocardial injury and
repair. This dichotomy is differentiated at the level of species type, amount and duration of …
repair. This dichotomy is differentiated at the level of species type, amount and duration of …
PMN-MDSCs enhance CTC metastatic properties through reciprocal interactions via ROS/Notch/Nodal signaling
ML Sprouse, T Welte, D Boral, HN Liu, W Yin… - International journal of …, 2019 - mdpi.com
Intratumoral infiltration of myeloid-derived suppressor cells (MDSCs) is known to promote
neoplastic growth by inhibiting the tumoricidal activity of T cells. However, direct interactions …
neoplastic growth by inhibiting the tumoricidal activity of T cells. However, direct interactions …
Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy
JH Kim, TG Choi, S Park, HR Yun… - Cell Death & …, 2018 - nature.com
Muscle differentiation is a crucial process controlling muscle development and homeostasis.
Mitochondrial reactive oxygen species (mtROS) rapidly increase and function as critical cell …
Mitochondrial reactive oxygen species (mtROS) rapidly increase and function as critical cell …
Selective inhibition of PI3K/Akt/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque
C Zhai, J Cheng, H Mujahid, H Wang, J Kong, Y Yin… - PloS one, 2014 - journals.plos.org
Macrophage infiltration contributes to the instability of atherosclerotic plaques. In the present
study, we investigated whether selective inhibition of PI3K/Akt/mTOR signaling pathway can …
study, we investigated whether selective inhibition of PI3K/Akt/mTOR signaling pathway can …
Cell-free circulating mitochondrial DNA: An emerging biomarker for airborne particulate matter associated with cardiovascular diseases
The association of airborne particulate matter exposure with the deteriorating function of the
cardiovascular system is fundamentally driven by the impairment of mitochondrial-nuclear …
cardiovascular system is fundamentally driven by the impairment of mitochondrial-nuclear …
Metabolic syndrome as a multifaceted risk factor for oxidative stress
Abstract Significance: Metabolic syndrome (MetS) is associated with a greater risk of
diabetes and cardiovascular diseases. It is estimated that this multifactorial condition affects …
diabetes and cardiovascular diseases. It is estimated that this multifactorial condition affects …
Astilbin protects chicken peripheral blood lymphocytes from cadmium-induced necroptosis via oxidative stress and the PI3K/Akt pathway
C Xin, S Guangliang, Z Qing, L Qingqing… - Ecotoxicology and …, 2020 - Elsevier
Astilbin (ASB), a dihydroflavonol glycoside, is widely found in a variety of plants and in
functional foods and acts as a powerful antioxidant. The aim of this study was to investigate …
functional foods and acts as a powerful antioxidant. The aim of this study was to investigate …
Interplay between mitochondrial metabolism and cellular redox state dictates cancer cell survival
BJA Foo, JQ Eu, JL Hirpara… - Oxidative Medicine and …, 2021 - Wiley Online Library
Mitochondria are the main powerhouse of the cell, generating ATP through the tricarboxylic
acid cycle (TCA) and oxidative phosphorylation (OXPHOS), which drives myriad cellular …
acid cycle (TCA) and oxidative phosphorylation (OXPHOS), which drives myriad cellular …
Regulatory role of HIF-1α in the pathogenesis of age-related macular degeneration (AMD)
O Arjamaa, M Nikinmaa, A Salminen… - Ageing research …, 2009 - Elsevier
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the
elderly throughout the world. AMD is attributed to a complex interaction of genetic and …
elderly throughout the world. AMD is attributed to a complex interaction of genetic and …