[HTML][HTML] High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Mechanisms and prevention of UV‐induced melanoma

A Sample, YY He - Photodermatology, photoimmunology & …, 2018 - Wiley Online Library
Melanoma is the deadliest form of skin cancer and its incidence is rising, creating a costly
and significant clinical problem. Exposure to ultraviolet (UV) radiation, namely UVA (315 …

[HTML][HTML] Role of vitamin C in skin diseases

K Wang, H Jiang, W Li, M Qiang, T Dong… - Frontiers in physiology, 2018 - frontiersin.org
Vitamin C (ascorbic acid) plays an important role in maintaining skin health and can promote
the differentiation of keratinocytes and decrease melanin synthesis, leading to antioxidant …

[HTML][HTML] Intravenous vitamin C for cancer therapy–identifying the current gaps in our knowledge

AC Carr, J Cook - Frontiers in physiology, 2018 - frontiersin.org
The use of intravenous vitamin C (IVC) for cancer therapy has long been an area of intense
controversy. Despite this, high dose IVC has been administered for decades by …

Oxidative stress and antioxidants in the pathophysiology of malignant melanoma

E Obrador, F Liu-Smith, RW Dellinger… - Biological …, 2019 - degruyter.com
The high number of somatic mutations in the melanoma genome associated with cumulative
ultra violet (UV) exposure has rendered it one of the most difficult of cancers to treat. With …

[HTML][HTML] High-dose vitamin C in advanced-stage cancer patients

A Zasowska-Nowak, PJ Nowak, A Ciałkowska-Rysz - Nutrients, 2021 - mdpi.com
High-dose intravenously administered vitamin C (IVC) is widely used in cancer patients by
complementary and alternative medicine practitioners. The most frequent indications for IVC …

Effect of high-dose vitamin C combined with anti-cancer treatment on breast cancer cells

SJ Lee, JH Jeong, IH Lee, J Lee, JH Jung… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: The anti-cancer effect of high doses of intravenous vitamin C (high-dose
vitamin C) remains controversial despite growing evidence that high-dose vitamin C exerts …

[HTML][HTML] Role of key micronutrients from nutrigenetic and nutrigenomic perspectives in cancer prevention

AI Irimie, C Braicu, S Pasca, L Magdo, D Gulei… - Medicina, 2019 - mdpi.com
Regarding cancer as a genetic multi-factorial disease, a number of aspects need to be
investigated and analyzed in terms of cancer's predisposition, development and prognosis …

[HTML][HTML] Vitamin C transporters and their implications in carcinogenesis

K Linowiecka, M Foksinski, AA Brożyna - Nutrients, 2020 - mdpi.com
Vitamin C is implicated in various bodily functions due to its unique properties in redox
homeostasis. Moreover, vitamin C also plays a great role in restoring the activity of 2 …

[HTML][HTML] Vitamin C: A stem cell promoter in cancer metastasis and immunotherapy

J Fu, Z Wu, J Liu, T Wu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Vitamin C is an electron donor and is involved in a variety of biochemical reactions in stem
cell and cancer stem cell, as well as collagen synthesis and the regulation of hypoxia …