Designing hydrogels for controlled drug delivery

J Li, DJ Mooney - Nature Reviews Materials, 2016 - nature.com
Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery
and have found clinical use. Hydrogels can provide spatial and temporal control over the …

pH sensitive hydrogels in drug delivery: Brief history, properties, swelling, and release mechanism, material selection and applications

M Rizwan, R Yahya, A Hassan, M Yar, AD Azzahari… - Polymers, 2017 - mdpi.com
Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed
rather than the development of novel drugs which involve much expense and time. The …

Bioinspired Spatiotemporal Management toward RNA Therapies

Y Ma, S Li, X Lin, Y Chen - ACS nano, 2023 - ACS Publications
Ribonucleic acid (RNA)-based therapies have become an attractive topic in disease
intervention, especially with some that have been approved by the FDA such as the mRNA …

Bio-inspired engineering of cell-and virus-like nanoparticles for drug delivery

A Parodi, R Molinaro, M Sushnitha, M Evangelopoulos… - Biomaterials, 2017 - Elsevier
The engineering of future generations of nanodelivery systems aims at the creation of
multifunctional vectors endowed with improved circulation, enhanced targeting and …

Strategic design of intelligent-responsive nanogel carriers for cancer therapy

H Wang, L Gao, T Fan, C Zhang, B Zhang… - … applied materials & …, 2021 - ACS Publications
Owing to the distinctive constituents of tumor tissue from those healthy organs,
nanomedicine strategies show significant potentials in smart drug delivery. Nowadays …

Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting

X Fu, Y Shi, T Qi, S Qiu, Y Huang, X Zhao… - Signal transduction and …, 2020 - nature.com
Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to
reach their final targets. The optimal targets of most cancer therapeutic agents are usually …

Recent developments in stimuli-responsive polymer nanogels for drug delivery and diagnostics: A review

NK Preman, RR Barki, A Vijayan, SG Sanjeeva… - European Journal of …, 2020 - Elsevier
Polymer nanogels (NGs) are water-swellable, cross-linked 3D network structures with size
typically range from 1 to 1000 nm. Especially, biocompatible and “smart” NGs engineered …

In situ onepot synthesis of MOF–polydopamine hybrid nanogels with enhanced photothermal effect for targeted cancer therapy

D Wang, H Wu, J Zhou, P Xu, C Wang, R Shi… - Advanced …, 2018 - Wiley Online Library
Herein, a simple onepot way is designed to prepare a type of multifunctional metal–organic
framework (MOF)based hybrid nanogels by in situ hybridization of dopamine monomer in …

Nanogels for intracellular delivery of biotherapeutics

D Li, CF van Nostrum, E Mastrobattista… - Journal of Controlled …, 2017 - Elsevier
Many biomolecules, such as proteins and genes, are presently used as therapeutics.
However, their delivery to target sites inside cells is challenging because of their large …

Recent advances in CXCL12/CXCR4 antagonists and nano-based drug delivery systems for cancer therapy

R Zhao, J Liu, Z Li, W Zhang, F Wang, B Zhang - Pharmaceutics, 2022 - mdpi.com
Chemokines can induce chemotactic cell migration by interacting with G protein-coupled
receptors to play a significant regulatory role in the development of cancer. CXC chemokine …