[HTML][HTML] Hierarchical ultrastructure: an overview of what is known about tendons and future perspective for tendon engineering

S Zhang, W Ju, X Chen, Y Zhao, L Feng, Z Yin… - Bioactive materials, 2022 - Elsevier
Abnormal tendons are rarely ever repaired to the natural structure and morphology of
normal tendons. To better guide the repair and regeneration of injured tendons through a …

Polarization-sensitive second harmonic generation microscopy for investigations of diseased collagenous tissues

R Cisek, A Joseph, MA Harvey, D Tokarz - Frontiers in Physics, 2021 - frontiersin.org
The advancement of non-invasive quantitative optical diagnosis techniques such as
polarization-sensitive second harmonic generation microscopy (PSHG) for diseases such as …

High numerical aperture imaging allows chirality measurement in individual collagen fibrils using polarization second harmonic generation microscopy

MA Harvey, R Cisek, M Alizadeh, V Barzda… - …, 2023 - degruyter.com
Second harmonic generation (SHG) microscopy is a commonly used technique to study the
organization of collagen within tissues. However, individual collagen fibrils, which have …

PSHG-TISS: A collection of polarization-resolved second harmonic generation microscopy images of fixed tissues

R Hristu, SG Stanciu, A Dumitru, LG Eftimie, B Paun… - Scientific Data, 2022 - nature.com
Second harmonic generation (SHG) microscopy is acknowledged as an established
imaging technique capable to provide information on the collagen architecture in tissues that …

[HTML][HTML] Establishment of a human 3D pancreatic adenocarcinoma model based on a patient-derived extracellular matrix scaffold

F Sensi, E D'angelo, A Biccari, A Marangio… - Translational …, 2023 - Elsevier
Pancreatic cancer is likely to become one of the leading causes of cancer-related death in
many countries within the next decade. Surgery is the potentially curative treatment for …

Machine learning-enabled cancer diagnostics with widefield polarimetric second-harmonic generation microscopy

K Mirsanaye, L Uribe Castaño, Y Kamaliddin… - Scientific reports, 2022 - nature.com
The extracellular matrix (ECM) collagen undergoes major remodeling during tumorigenesis.
However, alterations to the ECM are not widely considered in cancer diagnostics, due to …

Influence of hematoxylin and eosin staining on the quantitative analysis of second harmonic generation imaging of fixed tissue sections

R Hristu, SG Stanciu, A Dumitru, B Paun… - Biomedical Optics …, 2021 - opg.optica.org
Second harmonic generation (SHG) microscopy has emerged over the past two decades as
a powerful tool for tissue characterization and diagnostics. Its main applications in medicine …

Characterization of pathological thyroid tissue using polarization-sensitive second harmonic generation microscopy

D Tokarz, R Cisek, A Joseph, SL Asa… - Laboratory …, 2020 - nature.com
Polarization-sensitive second harmonic generation (SHG) microscopy is an established
imaging technique able to provide information related to specific molecular structures …

Effect of out of plane orientation on polarization second harmonic generation of single collagen fibrils

MA Harvey, R Cisek, D Tokarz… - Biomedical Optics Express, 2023 - opg.optica.org
Second harmonic generation (SHG) microscopy has emerged as a powerful technique for
visualizing collagen organization within tissues. Amongst the many advantages of SHG is its …

Unsupervised determination of lung tumor margin with widefield polarimetric second-harmonic generation microscopy

K Mirsanaye, L Uribe Castaño, Y Kamaliddin… - Scientific Reports, 2022 - nature.com
The extracellular matrix (ECM) is amongst many tissue components affected by cancer,
however, morphological changes of the ECM are not well-understood and thus, often …