Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

The population is aging at a rate never seen before in human history. As the number of
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …

Macrophage polarization refers to the process by which macrophages can produce two
distinct functional phenotypes: M1 or M2. The balance between both strongly affects the …

The role of NOD‐like receptor protein 3 (NLRP3)‐mediated pyroptosis in acute lung injury
(ALI) has been well identified previously. Stimulator of interferon genes (STING) is an …

Rationale: Hypertension represents a major risk factor for stroke, myocardial infarction, and
heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to …

Abstract Sirtuin 3 (SIRT3) is a potential therapeutic target for cardiovascular, metabolic, and
other aging-related diseases. In this study, we investigated the role of SIRT3 in diabetic …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening
conditions triggered by multiple intra-and extra-pulmonary injury factors, characterized by …

Stilbenes are polyphenolic allelochemicals synthesized by plants, especially grapes,
peanuts, rhubarb, berries, etc., to defend themselves under stressful conditions. They are …

The mitochondrial quality control of lung epithelial cells is disturbed during sepsis, which
contributes to abnormal mitochondrial function and acute lung injury. Melatonin is one of the …