Type 2 chronic inflammatory diseases: targets, therapies and unmet needs

P Kolkhir, CA Akdis, M Akdis, C Bachert… - Nature Reviews Drug …, 2023 - nature.com
Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …

Rhinitis associated with asthma is distinct from rhinitis alone: the ARIA‐MeDALL hypothesis

J Bousquet, E Melén, T Haahtela, GH Koppelman… - Allergy, 2023 - Wiley Online Library
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …

Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper

M Jutel, I Agache, M Zemelka‐Wiacek, M Akdis… - Allergy, 2023 - Wiley Online Library
The exponential growth of precision diagnostic tools, including omic technologies, molecular
diagnostics, sophisticated genetic and epigenetic editing, imaging and nano‐technologies …

Microplastics in the Bronchoalveolar lavage fluid of Chinese children: associations with age, City development, and disease features

C Chen, F Liu, S Quan, L Chen, A Shen… - … science & technology, 2023 - ACS Publications
This study characterized the occurrence patterns of microplastics (MPs) in the
bronchoalveolar lavage fluid (BALF) of children with pulmonary diseases. MPs were …

Laundry detergents and surfactants‐induced eosinophilic airway inflammation by increasing IL‐33 expression and activating ILC2s

K Saito, K Orimo, T Kubo, M Tamari, A Yamada… - Allergy, 2023 - Wiley Online Library
Introduction Epidemiological studies demonstrated that cleaning work and frequent use of
cleaning products are risk factors for asthma. Laundry detergents have been reported to …

Allergy: Mechanistic insights into new methods of prevention and therapy

CA Akdis, M Akdis, SD Boyd, V Sampath… - Science Translational …, 2023 - science.org
In the past few decades, the prevalence of allergic diseases has increased worldwide. Here,
we review the etiology and pathophysiology of allergic diseases, including the role of the …

Effects of air pollution on cellular senescence and skin aging

I Martic, P Jansen-Dürr, M Cavinato - Cells, 2022 - mdpi.com
The human skin is exposed daily to different environmental factors such as air pollutants and
ultraviolet (UV) light. Air pollution is considered a harmful environmental risk to human skin …

Mechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80

I Ogulur, D Yazici, Y Pat, EN Bingöl, H Babayev… - Allergy, 2023 - Wiley Online Library
Background The rising prevalence of many chronic diseases related to gut barrier
dysfunction coincides with the increased global usage of dietary emulsifiers in recent …

[HTML][HTML] Feast for thought: A comprehensive review of food allergy 2021-2023

I Bartha, N Almulhem, AF Santos - Journal of Allergy and Clinical …, 2024 - Elsevier
A review of the latest publications in food allergy over the past couple of years confirmed that
food allergy is a major public health concern, affecting about 8% of children and 10% of …

EAACI guidelines on environmental science in allergic diseases and asthma–leveraging artificial intelligence and machine learning to develop a causality model in …

MH Shamji, M Ollert, IM Adcock, O Bennett, A Favaro… - Allergy, 2023 - Wiley Online Library
Allergic diseases and asthma are intrinsically linked to the environment we live in and to
patterns of exposure. The integrated approach to understanding the effects of exposures on …