Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

Extracellular vesicles such as exosomes, microvesicles, apoptotic bodies, and large
oncosomes have been shown to participate in a wide variety of biological processes and are …

During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

The overall structure and architecture of the extracellular matrix undergo dramatic alterations
in composition, form, and functionality over time. The stochasticity begins during …

The heparan sulfate-degrading enzyme heparanase promotes the progression of many
cancers by driving tumor cell proliferation, metastasis and angiogenesis. Heparanase …

Sialylated N-glycans play essential roles in the immune system, pathogen recognition and
cancer. This review approaches the sialylation of N-glycans from three perspectives. The …

Emergence of the field of exosome biology has opened an exciting door to better
understand communication between cells. These tiny nanovesicles act as potent regulators …

Sialic acids are a group of nine-carbon α-keto acids. Sialic acid exists in more than 50 forms,
with the natural types discovered as N-acetylneuraminic acid (Neu5Ac), deaminoneuraminic …

Microglia are brain macrophages that mediate neuroinflammation and contribute to and
protect against neurodegeneration. The terminal sugar residue of all glycoproteins and …