NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology

A Vermot, I Petit-Härtlein, SME Smith, F Fieschi - Antioxidants, 2021 - mdpi.com
The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Plant phospholipases D and C and their diverse functions in stress responses

Y Hong, J Zhao, L Guo, SC Kim, X Deng, G Wang… - Progress in lipid …, 2016 - Elsevier
Abstract Phospholipases D (PLD) and C (PLC) hydrolyze the phosphodiesteric linkages of
the head group of membrane phospholipids. PLDs and PLCs in plants occur in different …

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

GR Drummond, S Selemidis, KK Griendling… - Nature reviews Drug …, 2011 - nature.com
NADPH oxidases are a family of enzymes that generate reactive oxygen species (ROS). The
NOX1 (NADPH oxidase 1) and NOX2 oxidases are the major sources of ROS in the artery …

NOX enzymes and the biology of reactive oxygen

JD Lambeth - Nature Reviews Immunology, 2004 - nature.com
Professional phagocytes generate high levels of reactive oxygen species (ROS) using a
superoxide-generating NADPH oxidase as part of their armoury of microbicidal …

From flies to men: ROS and the NADPH oxidase in phagocytes

ZM Moghadam, P Henneke, J Kolter - Frontiers in cell and …, 2021 - frontiersin.org
The cellular formation of reactive oxygen species (ROS) represents an evolutionary ancient
antimicrobial defense system against microorganisms. The NADPH oxidases (NOX), which …

Structure, regulation and evolution of Nox‐family NADPH oxidases that produce reactive oxygen species

H Sumimoto - The FEBS journal, 2008 - Wiley Online Library
NADPH oxidases of the Nox family exist in various supergroups of eukaryotes but not in
prokaryotes, and play crucial roles in a variety of biological processes, such as host defense …

The neutrophil NADPH oxidase

BM Babior, JD Lambeth, W Nauseef - Archives of biochemistry and …, 2002 - Elsevier
The NADPH oxidase of phagocytes catalyzes the conversion of oxygen to O− 2. This
multicomponent enzyme complex contains five essential protein components, two in the …

The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

PV Vignais - Cellular and Molecular Life Sciences CMLS, 2002 - Springer
Flavocytochrome b 558 is the catalytic core of the respiratory-burst oxidase, an enzyme
complex that catalyzes the NADPH-dependent reduction of O 2 into the superoxide anion O …

Activation and assembly of the NADPH oxidase: a structural perspective

Y Groemping, K Rittinger - Biochemical Journal, 2005 - portlandpress.com
The NADPH oxidase of professional phagocytes is a crucial component of the innate
immune response due to its fundamental role in the production of reactive oxygen species …

Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease

RD Teasdale, BM Collins - Biochemical Journal, 2012 - portlandpress.com
The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain,
responsible for membrane attachment to organelles of the secretory and endocytic system …