RNA interference (RNAi) is a major cellular mechanism regulating gene expression in which
short double-stranded RNA molecules called small interfering RNA (siRNA) mediate …

Peptide nucleic acids (PNAs) are an important class of DNA/RNA mimics that can hybridize
complementary chains of nucleic acids with high affinity and specificity. Because of this …

Monitoring diseases caused by pathogens or by mutations in DNA sequences requires
accurate, rapid, and sensitive tools to detect specific nucleic acid sequences. Here, we …

Peptide nucleic acid or PNA is a synthetic DNA mimic that contains a sequence of
nucleobases attached to a peptide-like backbone derived from N-2-aminoethylglycine. The …

Infectious diseases have threatened human life for as long as humankind has existed. One
of the most crucial aspects of fighting against these infections is diagnosis to prevent …

With recent advances in point-of-care testing, wearable electronics, and implantable medical
devices, there is a growing interest in developing state-of-the-art methods to monitor human …

The unique properties of peptide nucleic acid (PNA) makes it a desirable candidate to be
used in therapeutic and biotechnological interventions. It has been broadly utilized for …

Exchanging the ribose backbone of an oligonucleotide for a peptide can enhance its
physiologic stability and nucleic acid binding affinity. Ordinarily, the eneamino nitrogen atom …

Nucleic acid represents the ideal drug candidate for protein targets that are hard to target or
against which drug development is not easy. Peptide nucleic acids (PNAs) are synthesized …

Nucleic acids play a central role in human biology, making them suitable and attractive tools
for therapeutic applications. While conventional drugs generally target proteins and induce …