Therapeutic approaches for cardiac regeneration and repair

H Hashimoto, EN Olson, R Bassel-Duby - Nature Reviews Cardiology, 2018 - nature.com
Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …

Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions

SK Sanganalmath, R Bolli - Circulation research, 2013 - Am Heart Assoc
Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …

Pathophysiology of myocardial infarction

NG Frangogiannis - Comprehensive Physiology, 2011 - Wiley Online Library
Myocardial infarction is defined as sudden ischemic death of myocardial tissue. In the
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …

Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond

M Farina, JF Alexander, U Thekkedath, M Ferrari… - Advanced drug delivery …, 2019 - Elsevier
Cell-based therapy is emerging as a promising strategy for treating a wide range of human
diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and …

Stem cell therapy: a new therapeutic option for cardiovascular diseases

NH Goradel, FG Hour, B Negahdari… - Journal of cellular …, 2018 - Wiley Online Library
Cardiovascular diseases are known as one of major causes of morbidity and mortality
worldwide. Despite the many advancement in therapies are associated with cardiovascular …

Meta-analysis of cell therapy trials for patients with heart failure

SA Fisher, C Doree, A Mathur… - Circulation …, 2015 - Am Heart Assoc
Rationale: Cell-based therapies are a promising intervention for the treatment of heart failure
(HF) secondary to ischemic and nonischemic cardiomyopathy. However, the clinical efficacy …

Global position paper on cardiovascular regenerative medicine

F Fernández-Avilés, R Sanz-Ruiz… - European heart …, 2017 - academic.oup.com
Based on the increasingly understood regenerative capacity of the human heart and
vascular system, 1 cardiovascular regenerative medicine (CRM) encompasses all potential …

[HTML][HTML] Stem cells as therapy for heart disease: iPSCs, ESCs, CSCs, and skeletal myoblasts

R Rikhtegar, M Pezeshkian, S Dolati, N Safaie… - Biomedicine & …, 2019 - Elsevier
Heart Diseases are serious and global public health concern. In spite of remarkable
therapeutic developments, the prediction of patients with Heart Failure (HF) is weak, and …

Barth syndrome: cardiolipin, cellular pathophysiology, management, and novel therapeutic targets

HM Zegallai, GM Hatch - Molecular and cellular biochemistry, 2021 - Springer
Barth syndrome is a rare X-linked genetic disease classically characterized by
cardiomyopathy, skeletal myopathy, growth retardation, neutropenia, and 3 …

Programming and reprogramming a human heart cell

M Sahara, F Santoro, KR Chien - The EMBO journal, 2015 - embopress.org
The latest discoveries and advanced knowledge in the fields of stem cell biology and
developmental cardiology hold great promise for cardiac regenerative medicine, enabling …