KRAS: the critical driver and therapeutic target for pancreatic cancer
RAS genes (HRAS, KRAS, and NRAS) comprise the most frequently mutated oncogene
family in human cancer. With the highest RAS mutation frequencies seen with the top three …
family in human cancer. With the highest RAS mutation frequencies seen with the top three …
RAS isoforms and mutations in cancer at a glance
ABSTRACT RAS proteins (KRAS4A, KRAS4B, NRAS and HRAS) function as GDP–GTP-
regulated binary on-off switches, which regulate cytoplasmic signaling networks that control …
regulated binary on-off switches, which regulate cytoplasmic signaling networks that control …
Drugging the undruggable RAS: Mission possible?
AD Cox, SW Fesik, AC Kimmelman, J Luo… - Nature reviews Drug …, 2014 - nature.com
Despite more than three decades of intensive effort, no effective pharmacological inhibitors
of the RAS oncoproteins have reached the clinic, prompting the widely held perception that …
of the RAS oncoproteins have reached the clinic, prompting the widely held perception that …
Dragging ras back in the ring
AG Stephen, D Esposito, RK Bagni, F McCormick - Cancer cell, 2014 - cell.com
Ras proteins play a major role in human cancers but have not yielded to therapeutic attack.
Ras-driven cancers are among the most difficult to treat and often excluded from therapies …
Ras-driven cancers are among the most difficult to treat and often excluded from therapies …
Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery
CE Paulsen, KS Carroll - Chemical reviews, 2013 - ACS Publications
Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …
respectively, are produced during normal cell function and in response to various stimuli. An …
An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FeNO) for Clinical Applications
Background: Measurement of fractional nitric oxide (NO) concentration in exhaled breath
(FeNO) is a quantitative, noninvasive, simple, and safe method of measuring airway …
(FeNO) is a quantitative, noninvasive, simple, and safe method of measuring airway …
RAS interaction with PI3K: more than just another effector pathway
E Castellano, J Downward - Genes & cancer, 2011 - journals.sagepub.com
RAS proteins are small GTPases known for their involvement in oncogenesis: around 25%
of human tumors present mutations in a member of this family. RAS operates in a complex …
of human tumors present mutations in a member of this family. RAS operates in a complex …
Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
N Charles, T Ozawa, M Squatrito, AM Bleau… - Cell stem cell, 2010 - cell.com
Summary eNOS expression is elevated in human glioblastomas and correlated with
increased tumor growth and aggressive character. We investigated the potential role of nitric …
increased tumor growth and aggressive character. We investigated the potential role of nitric …
Protein S-nitrosylation in health and disease: a current perspective
Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on
cellular signal transduction and accumulating evidence indicates important roles for S …
cellular signal transduction and accumulating evidence indicates important roles for S …
In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras–effector interaction
F Shima, Y Yoshikawa, M Ye, M Araki… - Proceedings of the …, 2013 - National Acad Sciences
Mutational activation of the Ras oncogene products (H-Ras, K-Ras, and N-Ras) is frequently
observed in human cancers, making them promising anticancer drug targets. Nonetheless …
observed in human cancers, making them promising anticancer drug targets. Nonetheless …