The incretin hormone glucagon-like peptide 1 (GLP-1) has many effects in the body. It is best
known for the 'incretin effect', facilitating insulin release from the pancreas under …

The current understanding of neurodegenerative processes in sporadic diseases such as
Alzheimer's disease (AD), Parkinson's disease (PD) or multiple sclerosis is very limited …

Impaired intestinal epithelial barrier (IEB) function with loss of desmosomal junctional
protein desmoglein 2 (DSG2) is a hallmark in the pathogenesis of inflammatory bowel …

Surprisingly little is known about the mechanisms that trigger the onset of AD (Alzheimer's
disease) in sporadic forms. A number of risk factors have been identified that may shed light …

Diabetes is a risk factor for Alzheimer's disease. We tested the effects of Val (8) GLP-1, an
enzyme-resistant analogue of the incretin hormone glucagon-like peptide 1 originally …

For dominantly inherited disorders development of gene therapies, targeting the primary
genetic lesion has been impeded by mutational heterogeneity. An example is rhodopsin …

Developing new ways of delivering cells to diseased tissue will be a key factor in translating
cell therapeutics research into clinical use. Magnetically targeting cells enables delivery of …

Trophic factors are endogenously secreted proteins that act in an autocrine and/or paracrine
fashion to affect vital cellular processes such as proliferation, differentiation, and …

The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic
polypeptide (GIP) have been developed to treat type 2 diabetes and also act as growth …

Arsenic (As) is a toxic element, and long-term exposure to As can cause neurotoxicity. The
bioactive natural compound Dictyophora polysaccharide (DIP) from edible plants has been …