Extensive research on the Ras proteins and their functions in cell physiology over the past
30 years has led to numerous insights that have revealed the involvement of Ras not only in …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …

RAS proteins are small GTPases, which serve as master regulators of a myriad of signaling
cascades involved in highly diverse cellular processes. RAS oncogenes have been …

The initial discovery that ras genes endowed retroviruses with potent carcinogenic
properties and the subsequent determination that mutated ras genes were present in a wide …

Ha-, N-, and Ki-Ras are ubiquitously expressed in mammalian cells and can all interact with
the same set of effector proteins. We show here, however, that in vivo there are marked …

We have identified the PDZ domain protein AF-6 as an intracellular binding partner of the
junctional adhesion molecule (JAM), an integral membrane protein located at cell contacts …

A novel actin filament (F-actin)–binding protein with a molecular mass of∼ 205 kD (p205),
which was concentrated at cadherin-based cell-to-cell adherens junction (AJ), was isolated …

Abstract The MLL (Mixed Lineage Leukemia) gene is a common target for chromosomal
translocations associated with human acute leukemias. These translocations result in a gain …

Ras is a key regulator of cell growth in all eukaryotic cells. Genetic, biochemical, and
molecular studies in Caenorhabditis elegans, Drosophila, and mammalian cells have …