Cell-cell fusion between eukaryotic cells is a general process involved in many
physiological and pathological conditions, including infections by bacteria, parasites, and …

Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their
ability to establish lifelong latent infection in neurons. As for all herpesviruses …

ABSTRACT Herpes simplex virus 1 (HSV-1) causes a chronic, lifelong infection in> 60% of
adults. Multiple recent vaccine trials have failed, with viral diversity likely contributing to …

Herpes simplex virus type 1 (HSV-1) is a structurally complex enveloped dsDNA virus that
has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA …

The assembly and egress of herpes simplex virus (HSV) is a complicated multistage process
that involves several different cellular compartments and the activity of many viral and …

Herpes simplex virus (HSV)-1 dramatically alters the architecture and protein composition of
cellular membranes during infection, but its effects upon membrane lipid composition remain …

Herpes simplex virus mediates multiple distinct fusion events during infection. HSV entry is
initiated by fusion of the viral envelope with either the limiting membrane of a host cell …

Alphaherpesviruses, including pseudorabies virus (PRV), spread directionally within the
nervous systems of their mammalian hosts. Three viral membrane proteins are required for …

Here, we present a transformational approach to genome engineering of herpes simplex
virus type 1 (HSV-1), which has a large DNA genome, using synthetic genomics tools. We …

ABSTRACT A distinguishing morphological feature of all herpesviruses is the multiprotein
tegument layer located between the nucleocapsid and lipid envelope of the virion …