Breast cancer is a complex disease encompassing multiple tumor entities, each
characterized by distinct morphology, behavior and clinical implications. Besides estrogen …

Breast cancer (BC) is a heterogeneous disease, encompassing a diverse spectrum of
tumours with varying morphological, biological, and clinical phenotypes. Although tumours …

Tamoxifen is the most commonly used endocrine therapy for patients with hormone receptor
(HR)-positive breast cancer. Despite its initial therapeutic efficacy, many patients eventually …

Gene expression profiling has reshaped our understanding of breast cancer by defining and
characterizing four main intrinsic molecular subtypes: human epidermal growth factor …

Breast cancer is a heterogeneous disease with varied morphological appearances,
molecular features, behavior, and response to therapy. Current routine clinical management …

Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …

The International Agency for Research on Cancer (IARC) has recently reported a 66%
increase in the global number of cancer deaths since 1960. In the US alone, about one in …

This review discusses the results of DNA microarray signatures in breast cancer. These
signatures have been useful in the classification of breast cancers, and they have an …

Breast cancer is noted for disparate clinical behaviors and patient outcomes, despite
common histopathological features at diagnosis. Molecular pathogenesis studies suggest …

Breast cancer is a complex, multifaceted disease encompassing a great variety of entities
that show considerable variation in clinical, morphological and molecular attributes …