Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …

Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …

Obesity is a worldwide health problem, and as its prevalence increases, so does the burden
of obesity-associated co-morbidities like type 2 diabetes or cardiovascular diseases (CVDs) …

Obtained from the right cell-type, mesenchymal stromal cell (MSC)-derived small
extracellular vesicles (sEVs) promote stroke recovery. Within this process, microvascular …

Rationale: Necrosis is one of the main forms of cardiomyocyte death in heart disease.
Recent studies have demonstrated that certain types of necrosis are regulated and …

Hypoxia, the most commonly observed characteristic in cancers, is implicated in the
establishment of an immunosuppressive niche. Recent studies have indicated that …

Adipose-derived mesenchymal stem/stromal cells (ASCs) are an adult stem cell population
able to self-renew and differentiate into numerous cell lineages. ASCs provide a promising …

Stroke is one of the leading causes of death and physical disability worldwide. The
consequences of stroke injuries are profound and persistent, causing in considerable …

The optimal expression of endothelial nitric oxide synthase (eNOS), the hallmark of
endothelial homeostasis, is vital to vascular function. Dynamically regulated by various …

Stroke is the number one cause of neurological dysfunction in adults and has a heavy
socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting …