The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …

Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …

The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our
understanding of vasculogenesis and angiogenesis during development and physiological …

Angiogenesis is a double-edged sword; it is a mechanism that defines the boundary
between health and disease. In spite of its central role in physiological homeostasis, it …

Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …

Hypoxia plays a critical role during the evolution of malignant cells and tumour
microenvironment (TME). Tumour-derived exosomes contain informative microRNAs …

Several lines of evidence suggest that stress induces the neurovascular dysfunction
associated with increased blood–brain barrier (BBB) permeability, which could be an …

Vascular endothelial growth factors (VEGFs) are best known for their involvement in
orchestrating the development and maintenance of the blood and lymphatic vascular …

The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial
cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also …

Gallbladder cancer (GBC) is rare, but is the most malignant type of biliary tract tumor.
Unfortunately, only a small population of cancer patients is acceptable for the surgical …