Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer
JT Madak, A Bankhead III, CR Cuthbertson… - Pharmacology & …, 2019 - Elsevier
Identified as a hallmark of cancer, metabolic reprogramming allows cancer cells to rapidly
proliferate, resist chemotherapies, invade, metastasize, and survive a nutrient-deprived …
proliferate, resist chemotherapies, invade, metastasize, and survive a nutrient-deprived …
Of Wnts and ribosomes
AS Pfister, M Kühl - Progress in molecular biology and translational …, 2018 - Elsevier
Wnt proteins are secreted glycoproteins that activate different intracellular signal
transduction pathways. They regulate cell proliferation and are required for proper …
transduction pathways. They regulate cell proliferation and are required for proper …
Temporal dynamics of gene expression and histone marks at the Arabidopsis shoot meristem during flowering
Plants can produce organs throughout their entire life from pluripotent stem cells located at
their growing tip, the shoot apical meristem (SAM). At the time of flowering, the SAM of …
their growing tip, the shoot apical meristem (SAM). At the time of flowering, the SAM of …
[HTML][HTML] The Wnt/β-catenin pathway is activated as a novel nucleolar stress response
DP Dannheisig, J Bächle, J Tasic, M Keil… - Journal of Molecular …, 2021 - Elsevier
Ribosomes are mandatory for growth and survival. The complex process of ribosome
biogenesis is located in nucleoli and requires action of the RNA polymerases I–III, together …
biogenesis is located in nucleoli and requires action of the RNA polymerases I–III, together …
Specifying neural crest cells: From chromatin to morphogens and factors in between
Neural crest (NC) cells are a stem‐like multipotent population of progenitor cells that are
present in vertebrate embryos, traveling to various regions in the developing organism …
present in vertebrate embryos, traveling to various regions in the developing organism …
Prdm15 acts upstream of Wnt4 signaling in anterior neural development of Xenopus laevis
E Saumweber, S Mzoughi, A Khadra… - Frontiers in Cell and …, 2024 - frontiersin.org
Mutations in PRDM15 lead to a syndromic form of holoprosencephaly (HPE) known as the
Galloway–Mowat syndrome (GAMOS). While a connection between PRDM15, a zinc finger …
Galloway–Mowat syndrome (GAMOS). While a connection between PRDM15, a zinc finger …
Systematic mapping of rRNA 2'-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in …
Ribosomes are essential nanomachines responsible for protein production. Although
ribosomes are present in every living cell, ribosome biogenesis dysfunction diseases, called …
ribosomes are present in every living cell, ribosome biogenesis dysfunction diseases, called …
The Wnt target protein Peter Pan defines a novel p53-independent nucleolar stress-response pathway
AS Pfister, M Keil, M Kühl - Journal of Biological Chemistry, 2015 - ASBMB
Proper ribosome formation is a prerequisite for cell growth and proliferation. Failure of this
process results in nucleolar stress and p53-mediated apoptosis. The Wnt target Peter Pan …
process results in nucleolar stress and p53-mediated apoptosis. The Wnt target Peter Pan …
Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis
G Recher, J Jouralet, A Brombin, A Heuzé… - …, 2013 - journals.biologists.com
Investigating neural stem cell (NSC) behaviour in vivo, which is a major area of research,
requires NSC models to be developed. We carried out a multilevel characterisation of the …
requires NSC models to be developed. We carried out a multilevel characterisation of the …