Serum calcitonin negative medullary thyroid carcinoma: a systematic review of the literature

P Trimboli, L Giovanella - Clinical Chemistry and Laboratory …, 2015 - degruyter.com
Generally, calcitonin (CT) values below the upper reference limit rule-out medullary thyroid
carcinoma (MTC) with very high accuracy. However, sparse cases of serum-calcitonin …

Clinical challenges with calcitonin-negative medullary thyroid carcinoma

MT Samà, R Rossetto Giaccherino, M Gallo… - Journal of cancer …, 2016 - Springer
Purpose Medullary thyroid carcinoma (MTC) is a relatively uncommon malignant tumor of
the parafollicular C cells of the thyroid, which distinguishing feature is the production of …

Calcitonin negative Medullary Thyroid Carcinoma: a challenging diagnosis or a medical dilemma?

C Gambardella, C Offi, R Patrone, G Clarizia… - BMC endocrine …, 2019 - Springer
Background Medullary thyroid carcinoma is a neuroendocrine tumor belonging form a
malignant growth of the thyroid parafollicular C-cells, representing from 1 to 10% of all …

Prevalence and clinical spectrum of nonsecretory medullary thyroid carcinoma in a series of 839 patients with sporadic medullary thyroid carcinoma

K Frank-Raue, A Machens, G Leidig-Bruckner… - Thyroid, 2013 - liebertpub.com
Background: Medullary thyroid carcinoma (MTC) is characterized by the synthesis and
secretion of calcitonin (Ct). MTC without Ct secretion has been reported on rare occasions …

Serum calcitonin-negative medullary thyroid carcinoma: a case series of 19 patients in a single center

SJ Kim, HJ Yun, SJ Shin, YS Lee… - Frontiers in …, 2021 - frontiersin.org
Introduction Medullary thyroid carcinoma (MTC) is a rare cancer that accounts for 5% of
thyroid cancers. Serum calcitonin is a good biomarker for MTC, which is used for diagnosis …

Medullary thyroid cancer with undetectable serum calcitonin

EF Brutsaert, AJ Gersten, AB Tassler… - The Journal of Clinical …, 2015 - academic.oup.com
Context: Calcitonin is a sensitive biomarker that is used for diagnosis and follow-up in
medullary thyroid cancer (MTC). In patients with tumors> 1 cm, it is uncommon for …

Ca19. 9 positivity and doubling time are prognostic factors of mortality in patients with advanced medullary thyroid cancer with no evidence of structural disease …

L Lorusso, C Romei, P Piaggi, C Fustini, E Molinaro… - Thyroid, 2021 - liebertpub.com
Background: Serum Ca19. 9 positivity is a prognostic factor for mortality in patients with
advanced medullary thyroid cancer (aMTC), independently from calcitonin doubling time …

Medullary thyroid carcinoma with double negative calcitonin and CEA: a case report and update of literature review

C Gambardella, C Offi, G Clarizia, RM Romano… - BMC Endocrine …, 2019 - Springer
Background Medullary thyroid carcinoma is a malignant uncommon and aggressive tumour
of the parafollicular C cells. In about 75% of cases it is sporadic while, in case of RET …

Survival in patients with medullary thyroid cancer after less than the recommended initial operation

RW Randle, MF Bates, DF Schneider… - Journal of surgical …, 2018 - Wiley Online Library
Background and Objectives We aimed to evaluate the disease specific‐survival (DSS) of
patients with Medullary Thyroid Cancer (MTC) confined to the central neck based on the …

Utilizing the circulating tumor markers in diagnosis and management of medullary thyroid cancer

M Zarkesh, N Arab, SM Tavangar, Z Nozhat… - … -Research and Practice, 2022 - Elsevier
Medullary thyroid cancer (MTC) is the third frequent subtype of thyroid cancer-driving from
thyroid C-cells. The first-line strategy to treat MTC is surgery, but tumor recurrence and …