Conditioned place preference (CPP) continues to be one of the most popular models to
study the motivational effects of drugs and non‐drug treatments in experimental animals …

Acetaldehyde has long been suggested to be involved in a number of ethanol's
pharmacological and behavioral effects, such as its reinforcing, aversive, sedative, amnesic …

Tobacco use has one of the highest rates of addiction and relapse of any abused drug.
Paradoxically, however, in animal models of reinforcement nicotine appears weak …

This review evaluates the presumed contribution of acetaldehyde to tobacco smoke
addiction. In rodents, acetaldehyde induces reinforcing effects, and acts in concert with …

Ethanol non‐drinker (UChA) and drinker (UChB) rat lines derived from an original Wistar
colony have been selectively bred at the University of Chile for over 70 generations. Two …

Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied
in the 1940s, but then research interest in this compound waned. However, in the last two …

Acute alcohol intoxication causes cellular changes in the brain that last for hours, while
chronic alcohol use induces widespread neuroadaptations in the nervous system that can …

Introduction: This review identified published animal studies evaluating the possible abuse
potential of acetaldehyde, nornicotine, cotinine, and anabasine based on five commonly …

The putative contribution of brain acetaldehyde (AcH) to ethanol (EtOH) tolerance and
dependence (addiction) is reviewed. Although the role of AcH in EtOH addiction has been …

Background Published findings indicate that acetaldehyde (ACD; the first metabolite of
ethanol [E t OH]) and salsolinol (SAL; formed through the nonenzymatic condensation of …